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NAC062 NAC domain containing protein 62 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824115, updated on 18-Sep-2024

Summary

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Official Symbol
NAC062
Official Full Name
NAC domain containing protein 62
Primary source
TAIR:AT3G49530
Locus tag
AT3G49530
See related
Araport:AT3G49530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ANAC062; NAC domain containing protein 62; NTL6; NTM1 (NAC WITH TRANSMEMBRANE MOTIF 1)-LIKE 6
Summary
Transcription factor that serves as a molecular link between cold signals and pathogen resistance responses. Undergoes proteolytic processing triggered by cold-induced changes in membrane fluidity.
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Genomic context

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See NAC062 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
6
Sequence:
Chromosome: 3; NC_003074.8 (18362443..18364959, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box family protein Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene uncharacterized protein Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A plasma membrane-tethered transcription factor, NAC062/ANAC062/NTL6, mediates the unfolded protein response in Arabidopsis. Yang ZT, et al. Plant J, 2014 Sep. PMID 24961665
  2. Proteolytic processing of an Arabidopsis membrane-bound NAC transcription factor is triggered by cold-induced changes in membrane fluidity. Seo PJ, et al. Biochem J, 2010 Apr 14. PMID 20156199
  3. A membrane-bound NAC transcription factor as an integrator of biotic and abiotic stress signals. Seo PJ, et al. Plant Signal Behav, 2010 May. PMID 20139739, Free PMC Article
  4. Cold activation of a plasma membrane-tethered NAC transcription factor induces a pathogen resistance response in Arabidopsis. Seo PJ, et al. Plant J, 2010 Feb. PMID 19947982
  5. Controlled nuclear import of the transcription factor NTL6 reveals a cytoplasmic role of SnRK2.8 in the drought-stress response. Kim MJ, et al. Biochem J, 2012 Dec 15. PMID 22967043

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the membrane-associated transcription factor NAC062 relays endoplasmic reticulum (ER) stress signaling from the plasma membrane to the nucleus and plays important roles in regulating unfolded protein response (UPR)downstream gene expression.
    Title: A plasma membrane-tethered transcription factor, NAC062/ANAC062/NTL6, mediates the unfolded protein response in Arabidopsis.
  2. NTL6 plays an integrative role in plant responses to both biotic and abiotic stress conditions.
    Title: A membrane-bound NAC transcription factor as an integrator of biotic and abiotic stress signals.
  3. Transgenic plants overproducing either NTL6 or its active form 6deltaC exhibit enhanced resistance to water-deficit conditions.
    Title: Controlled nuclear import of the transcription factor NTL6 reveals a cytoplasmic role of SnRK2.8 in the drought-stress response.
  4. NTL6 activation is triggered by exposure to cold, and the transcriptionally active form of NTL6 induces the expression of PR genes by directly binding to the gene promoters and enhances plant resistance to pathogen infection.
    Title: Cold activation of a plasma membrane-tethered NAC transcription factor induces a pathogen resistance response in Arabidopsis.
  5. The observations indicate that a metalloprotease activity is responsible for NTL6 processing in response to cold-induced changes in membrane fluidity.
    Title: Proteolytic processing of an Arabidopsis membrane-bound NAC transcription factor is triggered by cold-induced changes in membrane fluidity.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001339427.1
NM_114813.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to other organism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NAC domain containing protein 62
NP_190522.1
  • NAC domain containing protein 62 (NAC062); CONTAINS InterPro DOMAIN/s: No apical meristem (NAM) protein (InterPro:IPR003441); BEST Arabidopsis thaliana protein match is: TCV-interacting protein (TAIR:AT5G24590.2); Has 2933 Blast hits to 2926 proteins in 76 species: Archae - 0; Bacteria - 2; Metazoa - 0; Fungi - 0; Plants - 2931; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    18362443..18364959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_114813.4 → NP_190522.1  NAC domain containing protein 62 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_190522.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SCK6
    UniProtKB/TrEMBL
    A0A178VG16, A0A5S9XJK4
    Conserved Domains (1) summary
    pfam02365
    Location:16 → 57
    NAM; No apical meristem (NAM) protein

  2. NM_001339427.1 → NP_001326200.1  NAC domain containing protein 62 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VG16, A0A1I9LNJ5, A0A5S9XJK4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SCK6.1

Gene LinkOut

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