U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MAPKKK20 mitogen-activated protein kinase kinase kinase 20 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824193, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
MAPKKK20
Official Full Name
mitogen-activated protein kinase kinase kinase 20
Primary source
TAIR:AT3G50310
Locus tag
AT3G50310
See related
Araport:AT3G50310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MAPKK kinase 20; mitogen-activated protein kinase kinase kinase 20; MKKK20
Summary
Encodes a member of MEKK subfamily. Target promoter of the male germline-specific transcription factor DUO1. Involved in osmotic stress response via regulation of MPK6 activity.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MAPKKK20 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
1
Sequence:
Chromosome: 3; NC_003074.8 (18648075..18649521, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Arabidopsis Mitogen-Activated Protein Kinase Kinase Kinase 20 (MKKK20) C-terminal domain interacts with MKK3 and harbors a typical DEF mammalian MAP kinase docking site. Bai F, et al. Plant Signal Behav, 2018. PMID 30081740, Free PMC Article
  2. Arabidopsis MKKK20 is involved in osmotic stress response via regulation of MPK6 activity. Kim JM, et al. Plant Cell Rep, 2012 Jan. PMID 21969089
  3. The Arabidopsis Mitogen-Activated Protein Kinase Kinase Kinase 20 (MKKK20) Acts Upstream of MKK3 and MPK18 in Two Separate Signaling Pathways Involved in Root Microtubule Functions. Benhamman R, et al. Front Plant Sci, 2017. PMID 28848569, Free PMC Article
  4. AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade. Li K, et al. Plant Physiol, 2017 Feb. PMID 27913741, Free PMC Article
  5. Wounding and Insect Feeding Trigger Two Independent MAPK Pathways with Distinct Regulation and Kinetics. Sözen C, et al. Plant Cell, 2020 Jun. PMID 32265268, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AT3G50310 (AIK1)-MKK5-MPK6 cascade functions in the abscisic acid regulation of primary root growth and stomatal response.
    Title: AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade.
  2. MKKK20 might be involved in the response to various abiotic stresses, especially osmotic stress, through its regulation of MPK6 activity. [MKKK20]
    Title: Arabidopsis MKKK20 is involved in osmotic stress response via regulation of MPK6 activity.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help
NM_114891.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen sperm cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of root meristem growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of stomatal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of unidimensional cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to reactive oxygen species IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
mitogen-activated protein kinase kinase kinase 20
NP_190600.1
  • mitogen-activated protein kinase kinase kinase 20 (MAPKKK20); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: mitogen-activated protein kinase kinase kinase 19 (TAIR:AT5G67080.1); Has 114114 Blast hits to 112767 proteins in 3610 species: Archae - 125; Bacteria - 11707; Metazoa - 43224; Fungi - 11427; Plants - 28864; Viruses - 487; Other Eukaryotes - 18280 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    18648075..18649521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_114891.2 → NP_190600.1  mitogen-activated protein kinase kinase kinase 20 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_190600.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A178VGW0, Q9SND6
    UniProtKB/TrEMBL
    A0A384LB13, A0A5S9XK63, Q8LCP0
    Conserved Domains (1) summary
    cd06606
    Location:2 → 268
    STKc_MAPKKK; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase Kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SND6.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools