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NOXY38 tetratricopeptide repeat (TPR)-containing protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824378, updated on 18-Sep-2024

Summary

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Official Symbol
NOXY38
Official Full Name
tetratricopeptide repeat (TPR)-containing protein
Primary source
TAIR:AT3G52140
Locus tag
AT3G52140
See related
Araport:AT3G52140
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
FMT; FRIENDLY; FRIENDLY MITOCHONDRIA; non responding to oxylipins 38
Summary
Involved in regulating mitochondrial quality control. Regulates mitochondrial association time and thereby is involved in mitochondrial fusion. Mutants show unregulated autophagy and display transcriptomic markers of mitochondrial stress.
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Genomic context

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See NOXY38 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
29
Sequence:
Chromosome: 3; NC_003074.8 (19332828..19341739)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene SWAP (Suppressor-of-White-APricot)/surp domain-containing protein / D111/G-patch domain-containing protein Neighboring gene ncRNA Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene ncRNA Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene Phosphoglycerate mutase family protein Neighboring gene 3-ketoacyl-CoA synthase 15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FRIENDLY is required for efficient dark-induced mitophagy and controlled senescence in Arabidopsis. Kacprzak SM, et al. Free Radic Biol Med, 2023 Aug 1. PMID 37085125
  2. FMT, a protein that affects mitochondrial distribution, interacts with translation-related proteins in Arabidopsis thaliana. Ayabe H, et al. Plant Cell Rep, 2021 Feb. PMID 33385240
  3. FRIENDLY regulates mitochondrial distribution, fusion, and quality control in Arabidopsis. El Zawily AM, et al. Plant Physiol, 2014 Oct. PMID 25165398, Free PMC Article
  4. The genetic control of plant mitochondrial morphology and dynamics. Logan DC, et al. Plant J, 2003 Nov. PMID 14617080
  5. Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice. Ralevski A, et al. Cell Mol Life Sci, 2022 Jun 2. PMID 35652974, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FRIENDLY is required for efficient dark-induced mitophagy and controlled senescence in Arabidopsis.
    Title: FRIENDLY is required for efficient dark-induced mitophagy and controlled senescence in Arabidopsis.
  2. Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice.
    Title: Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice.
  3. FMT, a protein that affects mitochondrial distribution, interacts with translation-related proteins in Arabidopsis thaliana.
    Title: FMT, a protein that affects mitochondrial distribution, interacts with translation-related proteins in Arabidopsis thaliana.
  4. Studies indicate taht the noxy38 mutation was mapped at the FRIENDLY MITOCHONDRIA (FMT) locus At3g52140.
    Title: Defense activated by 9-lipoxygenase-derived oxylipins requires specific mitochondrial proteins.
  5. Required for the correct cellular distribution of mitochondria.
    Title: The genetic control of plant mitochondrial morphology and dynamics.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_115073.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chloroplast localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular distribution of mitochondria IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat (TPR)-containing protein
NP_001190066.1
  • tetratricopeptide repeat (TPR)-containing protein; FUNCTIONS IN: binding; INVOLVED IN: biological_process unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT4G28080.1).
NP_001190067.1
  • tetratricopeptide repeat (TPR)-containing protein; FUNCTIONS IN: binding; INVOLVED IN: biological_process unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT4G28080.1).
NP_001190068.1
  • tetratricopeptide repeat (TPR)-containing protein; FUNCTIONS IN: binding; INVOLVED IN: biological_process unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT4G28080.1).
NP_190782.3
  • tetratricopeptide repeat (TPR)-containing protein; FUNCTIONS IN: binding; INVOLVED IN: biological_process unknown; LOCATED IN: plasma membrane, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT1G01320.2); Has 11101 Blast hits to 3590 proteins in 410 species: Archae - 113; Bacteria - 3115; Metazoa - 4880; Fungi - 1415; Plants - 408; Viruses - 9; Other Eukaryotes - 1161 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    19332828..19341739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001203139.1 → NP_001190068.1  tetratricopeptide repeat (TPR)-containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190068.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FF29, F4J5R9
    Conserved Domains (7) summary
    sd00006
    Location:1079 → 1114
    TPR; TPR repeat [structural motif]
    pfam05303
    Location:290 → 358
    DUF727; Protein of unknown function (DUF727)
    pfam12807
    Location:827 → 1009
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:411 → 681
    CLU; Clustered mitochondria
    pfam13374
    Location:1162 → 1203
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:1159 → 1234
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:126 → 203
    CLU_N; Mitochondrial function, CLU-N-term

  2. NM_001203138.1 → NP_001190067.1  tetratricopeptide repeat (TPR)-containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190067.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FF29, F4J5S0
    Conserved Domains (7) summary
    sd00006
    Location:1056 → 1091
    TPR; TPR repeat [structural motif]
    pfam05303
    Location:290 → 358
    DUF727; Protein of unknown function (DUF727)
    pfam12807
    Location:827 → 986
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:411 → 681
    CLU; Clustered mitochondria
    pfam13374
    Location:1139 → 1180
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:1136 → 1211
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:126 → 203
    CLU_N; Mitochondrial function, CLU-N-term

  3. NM_001203137.1 → NP_001190066.1  tetratricopeptide repeat (TPR)-containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190066.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4J5S1, F4J5S2, Q9SUZ1
    UniProtKB/TrEMBL
    A0A654FF29
    Conserved Domains (7) summary
    sd00006
    Location:1067 → 1102
    TPR; TPR repeat [structural motif]
    pfam05303
    Location:290 → 358
    DUF727; Protein of unknown function (DUF727)
    pfam12807
    Location:815 → 997
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:411 → 669
    CLU; Clustered mitochondria
    pfam13374
    Location:1150 → 1191
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:1147 → 1222
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:126 → 203
    CLU_N; Mitochondrial function, CLU-N-term

  4. NM_115073.5 → NP_190782.3  tetratricopeptide repeat (TPR)-containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_190782.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VKH1, A0A654FF29
    Conserved Domains (6) summary
    sd00006
    Location:1063 → 1098
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:1145 → 1219
    TPR_12; Tetratricopeptide repeat
    pfam05303
    Location:256 → 358
    DUF727; Protein of unknown function (DUF727)
    pfam12807
    Location:813 → 993
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:411 → 669
    CLU; Clustered mitochondria
    pfam15044
    Location:128 → 203
    CLU_N; Mitochondrial function, CLU-N-term
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4J5S1.1

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