uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS) [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Full Name: uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS)
Primary source: TAIR:AT3G54470
Locus tag: AT3G54470
See related: Araport:AT3G54470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Summary: encodes the bi-functional orotate phosphoribosyltransferase/orotidine-5'-phosphate decarboxylase catalyzing the fifth and sixth step in the de novo pyrimidine ribonucleotide biosynthesis
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 6

Sequence:: Chromosome: 3; NC_003074.8 (20168005..20170320, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_148875.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables orotate phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables orotate phosphoribosyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables orotidine-5'-phosphate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables orotidine-5'-phosphate decarboxylase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to phosphate starvation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within pyrimidine ribonucleotide biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

Go to the top of the page Help

Preferred Names: uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS)

NP_680130.1

uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); FUNCTIONS IN: orotate phosphoribosyltransferase activity, orotidine-5'-phosphate decarboxylase activity; INVOLVED IN: response to cadmium ion, cellular response to phosphate starvation, pyrimidine ribonucleotide biosynthetic process, nucleoside metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Orotidine 5'-phosphate decarboxylase, subfamily 1, core (InterPro:IPR014732), Orotidine 5'-phosphate decarboxylase, active site (InterPro:IPR018089), Ribulose-phosphate binding barrel (InterPro:IPR011060), Phosphoribosyltransferase (InterPro:IPR000836), Orotate phosphoribosyl transferase (InterPro:IPR004467), Orotidine 5'-phosphate decarboxylase, core (InterPro:IPR001754); Has 9174 Blast hits to 9124 proteins in 2964 species: Archae - 386; Bacteria - 5538; Metazoa - 208; Fungi - 955; Plants - 89; Viruses - 3; Other Eukaryotes - 1995 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

20168005..20170320 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_148875.5 → NP_680130.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS) [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q42586, Q9M1I0

UniProtKB/TrEMBL

A0A178V9W3, A0A5S9XKR6, A0A654FHX0

Conserved Domains (2) summary

pfam00215
Location:243 → 462

OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family

cl00309
Location:7 → 199

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain