HTA11 histone H2A 11 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HTA11
Official Full Name: histone H2A 11
Primary source: TAIR:AT3G54560
Locus tag: AT3G54560
See related: Araport:AT3G54560
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: histone H2A 11
Summary: Encodes HTA11, a histone H2A protein. Loss of all H2A.Z (triple mutant with HTA8 and HTA9) results in a reduction in DNA methylation of transposons but not that of genes. Loss of H2A.Z causes misregulation of many genes involved in the response to developmental and environmental cues, and that these genes tend to have high levels of gene-body H2A.Z.
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Genomic context

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See HTA11 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 3

Sequence:: Chromosome: 3; NC_003074.8 (20196140..20197726)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggests an antagonistic role between H2A.Z and H3K4me3 in the regulation of the expression of anthocyanin biosynthetic genes, highlighting a role of chromatin in gene regulation and reflecting the complexity of gene regulatory mechanisms.s [H2A.Z] [HTA11]
Title: Epigenetic regulation of anthocyanin biosynthesis by an antagonistic interaction between H2A.Z and H3K4me3.
YAF9A binds FLC chromatin and that YAF9 proteins regulate FLC expression by modulating the acetylation levels of H2A.Z and H4 but not H2A.Z deposition.[H2A.z]
Title: Arabidopsis YAF9 histone readers modulate flowering time through NuA4-complex-dependent H4 and H2A.Z histone acetylation at FLC chromatin.
MBD9 is a SWR1-C interacting protein required for H2A.Z deposition at a subset of actively transcribing genes. [H2A.Z]
Title: Arabidopsis SWR1-associated protein methyl-CpG-binding domain 9 is required for histone H2A.Z deposition.
HDA9 permits net eviction of the H2A.Z histone variant from nucleosomes associated with YUCCA8, allowing binding and transcriptional activation by PHYTOCHROME INTERACTING FACTOR 4, followed by auxin accumulation and thermomorphogenesis. [H2A.Z]
Title: HISTONE DEACETYLASE 9 stimulates auxin-dependent thermomorphogenesis in Arabidopsis thaliana by mediating H2A.Z depletion.
H2A.Z can be monoubiquitinated by the PRC1 components AtBMI1A/B/C. It is proposed that H2A.Z monoubiquitination plays a crucial role in transcriptional repression and, most probably, H2A.Z acetylation in transcriptional activation, while the different levels of H2A.Z along the genes may be a consequence of gene activity rather than an active mechanism to establish repression. [H2A.Z]
Title: The repressive role of Arabidopsis H2A.Z in transcriptional regulation depends on AtBMI1 activity.
Results show that H2A.Z-containing nucleosomes provide thermosensory information that is used to coordinate the ambient temperature transcriptome. [HTA11]
Title: H2A.Z-containing nucleosomes mediate the thermosensory response in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001339683.1

Supported by ESTs:

NM_115313.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within detection of temperature stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within flower development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: histone H2A 11

NP_191019.1

histone H2A 11 (HTA11); FUNCTIONS IN: DNA binding; INVOLVED IN: flower development, detection of temperature stimulus, defense response to bacterium; LOCATED IN: nucleus, nucleosome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Histone H2A (InterPro:IPR002119), Histone-fold (InterPro:IPR009072), Histone core (InterPro:IPR007125); BEST Arabidopsis thaliana protein match is: histone H2A 8 (TAIR:AT2G38810.2); Has 3864 Blast hits to 3859 proteins in 326 species: Archae - 0; Bacteria - 0; Metazoa - 2525; Fungi - 296; Plants - 612; Viruses - 2; Other Eukaryotes - 429 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

20196140..20197726

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_115313.5 → NP_191019.1 histone H2A 11 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191019.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O23628

UniProtKB/TrEMBL

A0A178V944, A0A384KLN3, Q0WS87

Conserved Domains (1) summary

PLN00154
Location:1 → 136

PLN00154; histone H2A; Provisional
NM_001339683.1 → NP_001325682.1 histone H2A 11 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O23628

UniProtKB/TrEMBL

A0A178V944, A0A384KLN3, Q0WS87

Conserved Domains (1) summary

PLN00154
Location:1 → 136

PLN00154; histone H2A; Provisional