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HIT3 HIS triad family protein 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824816, updated on 18-Sep-2024

Summary

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Official Symbol
HIT3
Official Full Name
HIS triad family protein 3
Primary source
TAIR:AT3G56490
Locus tag
AT3G56490
See related
Araport:AT3G56490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
HINT1; HIS triad family protein 3; HISTIDINE TRIAD NUCLEOTIDE-BINDING 1
Summary
Encodes a protein that has adenylylsulfate sulfohydrolase activity (E.C. 3.6.2.1) in vitro.
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Genomic context

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See HIT3 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
5
Sequence:
Chromosome: 3; NC_003074.8 (20941285..20943469)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box family protein Neighboring gene ncRNA Neighboring gene myosin heavy chain-like protein Neighboring gene ncRNA Neighboring gene serine-rich protein-like protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene NAC (No Apical Meristem) domain transcriptional regulator superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vivo subcellular targeting analysis validates a novel peroxisome targeting signal type 2 and the peroxisomal localization of two proteins with putative functions in defense in Arabidopsis. Quan S, et al. Plant Signal Behav, 2010 Feb. PMID 20009535, Free PMC Article
  2. Dual activity of certain HIT-proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5'-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP). Guranowski A, et al. FEBS Lett, 2010 Jan 4. PMID 19896942
  3. In-depth proteome analysis of Arabidopsis leaf peroxisomes combined with in vivo subcellular targeting verification indicates novel metabolic and regulatory functions of peroxisomes. Reumann S, et al. Plant Physiol, 2009 May. PMID 19329564, Free PMC Article
  4. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475
  5. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_115507.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables adenylylsulfatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within purine ribonucleotide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sulfur compound metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in extracellular region ISM
Inferred from Sequence Model
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
located_in secretory vesicle HDA PubMed 

General protein information

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Preferred Names
HIS triad family protein 3
NP_567038.1
  • HIS triad family protein 3 (HIT3); FUNCTIONS IN: protein kinase C binding, adenylylsulfatase activity, zinc ion binding; INVOLVED IN: sulfur metabolic process, purine ribonucleotide metabolic process; LOCATED IN: peroxisome, plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Histidine triad-like motif (InterPro:IPR011146), Histidine triad, conserved site (InterPro:IPR019808), Histidine triad (HIT) protein (InterPro:IPR001310), Histidine triad motif (InterPro:IPR011151); BEST Arabidopsis thaliana protein match is: HISTIDINE TRIAD NUCLEOTIDE-BINDING 2 (TAIR:AT1G31160.1); Has 7957 Blast hits to 7956 proteins in 2592 species: Archae - 148; Bacteria - 4849; Metazoa - 343; Fungi - 139; Plants - 127; Viruses - 0; Other Eukaryotes - 2351 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    20941285..20943469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115507.4 → NP_567038.1  HIS triad family protein 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567038.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8GUN2, Q9LXZ1
    UniProtKB/TrEMBL
    A0A178VI77, A0A5S9XLM2
    Conserved Domains (1) summary
    cd01276
    Location:35 → 139
    PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8GUN2.1

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