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MTHFR1 methylenetetrahydrofolate reductase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825167, updated on 18-Sep-2024

Summary

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Official Symbol
MTHFR1
Official Full Name
methylenetetrahydrofolate reductase 1
Primary source
TAIR:AT3G59970
Locus tag
AT3G59970
See related
Araport:AT3G59970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
methylenetetrahydrofolate reductase 1
Summary
methylenetetrahydrofolate reductase MTHFR1 mRNA, complete
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Genomic context

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See MTHFR1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
10
Sequence:
Chromosome: 3; NC_003074.8 (22151164..22154483)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Peptidase family C54 protein Neighboring gene ncRNA Neighboring gene histone-lysine N-methyltransferase ASHH4 Neighboring gene ncRNA Neighboring gene Nucleic acid-binding, OB-fold-like protein Neighboring gene methionine aminopeptidase 2B Neighboring gene QWRF motif protein (DUF566)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
  2. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
  3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_115860.4
NM_180392.1
NM_180393.1

Gene Ontology Provided by TAIR

Process Evidence Code Pubs
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
methylenetetrahydrofolate reductase 1
NP_191556.1
  • methylenetetrahydrofolate reductase 1 (MTHFR1); FUNCTIONS IN: methylenetetrahydrofolate reductase (NADPH) activity; INVOLVED IN: oxidation reduction, methionine metabolic process; EXPRESSED IN: fruit, guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Methylenetetrahydrofolate reductase (InterPro:IPR003171), Eukaryotic-type methylenetetrahydrofolate reductase (InterPro:IPR004621); BEST Arabidopsis thaliana protein match is: methylenetetrahydrofolate reductase 2 (TAIR:AT2G44160.1); Has 4753 Blast hits to 4742 proteins in 1927 species: Archae - 14; Bacteria - 3601; Metazoa - 134; Fungi - 280; Plants - 73; Viruses - 0; Other Eukaryotes - 651 (source: NCBI BLink).
NP_850723.1
  • methylenetetrahydrofolate reductase 1 (MTHFR1); FUNCTIONS IN: methylenetetrahydrofolate reductase (NADPH) activity; INVOLVED IN: oxidation reduction, methionine metabolic process; EXPRESSED IN: fruit, guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Methylenetetrahydrofolate reductase (InterPro:IPR003171), Eukaryotic-type methylenetetrahydrofolate reductase (InterPro:IPR004621); BEST Arabidopsis thaliana protein match is: methylenetetrahydrofolate reductase 2 (TAIR:AT2G44160.1); Has 4714 Blast hits to 4712 proteins in 1919 species: Archae - 14; Bacteria - 3588; Metazoa - 129; Fungi - 271; Plants - 66; Viruses - 0; Other Eukaryotes - 646 (source: NCBI BLink).
NP_850724.1
  • methylenetetrahydrofolate reductase 1 (MTHFR1); FUNCTIONS IN: methylenetetrahydrofolate reductase (NADPH) activity; INVOLVED IN: oxidation reduction, methionine metabolic process; EXPRESSED IN: fruit, guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Methylenetetrahydrofolate reductase (InterPro:IPR003171), Eukaryotic-type methylenetetrahydrofolate reductase (InterPro:IPR004621); BEST Arabidopsis thaliana protein match is: methylenetetrahydrofolate reductase 2 (TAIR:AT2G44160.1); Has 4714 Blast hits to 4712 proteins in 1919 species: Archae - 14; Bacteria - 3588; Metazoa - 129; Fungi - 271; Plants - 66; Viruses - 0; Other Eukaryotes - 646 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    22151164..22154483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115860.4 → NP_191556.1  methylenetetrahydrofolate reductase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191556.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3EAG9, Q9SE60
    UniProtKB/TrEMBL
    A0A178VC94, A0A5S9XP49
    Conserved Domains (1) summary
    PLN02540
    Location:18 → 582
    PLN02540; methylenetetrahydrofolate reductase

  2. NM_180392.1 → NP_850723.1  methylenetetrahydrofolate reductase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850723.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SE60
    Conserved Domains (1) summary
    cl00246
    Location:18 → 397
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  3. NM_180393.1 → NP_850724.1  methylenetetrahydrofolate reductase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850724.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4JAK1
    Conserved Domains (1) summary
    cl00246
    Location:18 → 397
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SE60.1

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