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DL1E DYNAMIN-like 1E [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825189, updated on 18-Sep-2024

Summary

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Official Symbol
DL1E
Official Full Name
DYNAMIN-like 1E
Primary source
TAIR:AT3G60190
Locus tag
AT3G60190
See related
Araport:AT3G60190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ADL1E; ADL4; ADLP2; ARABIDOPSIS DYNAMIN-LIKE 4; DRP1E; DYNAMIN-like 1E; DYNAMIN-LIKE PROTEIN 2; DYNAMIN-RELATED PROTEIN 1E; EDR3; ENHANCED DISEASE RESISTANCE 3; F27H5.4
Summary
At3g60190 encodes Arabidopsis dynamin-related protein 1E, DRP1E, also known as EDR3, ADL4 and ADL1E, which is 624 amino acid residues long, has a predicted mass of 69.8 kDa and a pI of 7.5. Dynamin-related protein 1E belongs to a plant-specific subclass of dynamin-related proteins (DRP1), consisting of five members in Arabidopsis (A, B, C, D, E). This class is characterized by having an N-terminal GTPase domain, a central #Aeodynamin 2#Aeo domain and a C-terminal GTPase effector domain (GED), a typical structure for plant dynamin-related proteins. However, this class lacks a PH domain and a proline-rich domain, which are found in classical animal dynamin-like proteins. Based on work on animal dynamins, the plant DRP1 proteins should be able to form polymeric structures that wrap around membranes to facilitate membrane tubulation and pinching off of vesicles, processes that are essential to vesicle trafficking and membrane compartmentalization. The edr3 mutation causes a P77L substitution in the G2 motif of the GTPase domain of DRP1E. edr3 mutant Arabidopsis plants display enhanced cell death in response to powdery mildew infection.
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Genomic context

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See DL1E in Genome Data Viewer
Location:
chromosome: 3
Exon count:
15
Sequence:
Chromosome: 3; NC_003074.8 (22244169..22247976, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene uncharacterized protein Neighboring gene GroES-like family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A mutation in the GTP hydrolysis site of Arabidopsis dynamin-related protein 1E confers enhanced cell death in response to powdery mildew infection. Tang D, et al. Plant J, 2006 Jul. PMID 16824181, Free PMC Article
  2. The arabidopsis cell plate-associated dynamin-like protein, ADL1Ap, is required for multiple stages of plant growth and development. Kang BH, et al. Plant Physiol, 2001 May. PMID 11351070, Free PMC Article
  3. The brassinosteroid insensitive1-like3 signalosome complex regulates Arabidopsis root development. Fàbregas N, et al. Plant Cell, 2013 Sep. PMID 24064770, Free PMC Article
  4. Interactome of the plant-specific ESCRT-III component AtVPS2.2 in Arabidopsis thaliana. Ibl V, et al. J Proteome Res, 2012 Jan 1. PMID 22010978, Free PMC Article
  5. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The edr3 mutant suggests a mechanistic link between salicylic acid signaling, mitochondria and programmed cell death in plants.
    Title: A mutation in the GTP hydrolysis site of Arabidopsis dynamin-related protein 1E confers enhanced cell death in response to powdery mildew infection.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_115882.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
DYNAMIN-like 1E
NP_567094.1
  • DYNAMIN-like 1E (DL1E); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: response to cadmium ion, vesicle-mediated transport, defense response to fungus; LOCATED IN: mitochondrion, plasma membrane, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin GTPase effector (InterPro:IPR003130), Dynamin, GTPase domain (InterPro:IPR001401), Dynamin, GTPase region, conserved site (InterPro:IPR019762), GTPase effector domain, GED (InterPro:IPR020850), Dynamin central region (InterPro:IPR000375); BEST Arabidopsis thaliana protein match is: DYNAMIN-like 1D (TAIR:AT2G44590.3); Has 2915 Blast hits to 2753 proteins in 324 species: Archae - 2; Bacteria - 53; Metazoa - 1058; Fungi - 869; Plants - 577; Viruses - 0; Other Eukaryotes - 356 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    22244169..22247976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115882.4 → NP_567094.1  DYNAMIN-like 1E [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567094.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FNX5, Q9M1C4, Q9SE82
    UniProtKB/TrEMBL
    A0A5S9XN78, A0A654FJF4
    Conserved Domains (3) summary
    cd08771
    Location:40 → 306
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:228 → 493
    Dynamin_M; Dynamin central region
    pfam02212
    Location:531 → 620
    GED; Dynamin GTPase effector domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FNX5.1

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