SLD1 Fatty acid/sphingolipid desaturase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SLD1
Official Full Name: Fatty acid/sphingolipid desaturase
Primary source: TAIR:AT3G61580
Locus tag: AT3G61580
See related: Araport:AT3G61580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtSLD1; sphingoid LCB desaturase 1
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Genomic context

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See SLD1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 1

Sequence:: Chromosome: 3; NC_003074.8 (22786022..22787972)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AtSLD1 and AtSLD2 are responsible for all of the sphingolipid Delta8 unsaturation in Arabidopsis, and AtSLD1 is the predominant contributor to unsaturation in all of the organs examined.
Title: Sphingolipid Δ8 unsaturation is important for glucosylceramide biosynthesis and low-temperature performance in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_116023.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables sphingolipid 8-(E/Z)-desaturase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Fatty acid/sphingolipid desaturase

NP_191717.1

Fatty acid/sphingolipid desaturase; CONTAINS InterPro DOMAIN/s: Fatty acid desaturase, type 1 (InterPro:IPR005804), Fatty acid/sphingolipid desaturase (InterPro:IPR012171), Cytochrome b5 (InterPro:IPR001199); BEST Arabidopsis thaliana protein match is: Fatty acid/sphingolipid desaturase (TAIR:AT2G46210.1); Has 5416 Blast hits to 5306 proteins in 857 species: Archae - 2; Bacteria - 1062; Metazoa - 955; Fungi - 1609; Plants - 915; Viruses - 2; Other Eukaryotes - 871 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

22786022..22787972

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116023.2 → NP_191717.1 Fatty acid/sphingolipid desaturase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191717.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LB96, Q9ZRP7

UniProtKB/TrEMBL

A0A178V7U9, A0A5S9XN41

Conserved Domains (2) summary

cd03506
Location:143 → 404

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...

pfam00173
Location:11 → 82

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain