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ABCB21 P-glycoprotein 21 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825388, updated on 18-Sep-2024

Summary

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Official Symbol
ABCB21
Official Full Name
P-glycoprotein 21
Primary source
TAIR:AT3G62150
Locus tag
AT3G62150
See related
Araport:AT3G62150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATP-binding cassette B21; P-glycoprotein 21; PGP21
Summary
Encodes a facultative transporter controlling auxin concentrations in plant cells.
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Genomic context

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See ABCB21 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Sequence:
Chromosome: 3; NC_003074.8 (23008653..23014030, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Class II aaRS and biotin synthetases superfamily protein Neighboring gene Pyridoxal phosphate (PLP)-dependent transferases superfamily protein Neighboring gene NEFA-interacting nuclear protein Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene VANGUARD-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis ABCB21 is a facultative auxin importer/exporter regulated by cytoplasmic auxin concentration. Kamimoto Y, et al. Plant Cell Physiol, 2012 Dec. PMID 23147222
  2. Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry. Nühse TS, et al. Mol Cell Proteomics, 2003 Nov. PMID 14506206
  3. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
  4. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812
  5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABCB21 functions as a facultative importer/exporter controlling auxin concentrations in plant cells.
    Title: Arabidopsis ABCB21 is a facultative auxin importer/exporter regulated by cytoplasmic auxin concentration.
Submit: New GeneRIF Correction

General gene information

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NM_116080.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables auxin efflux transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables auxin influx transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within auxin export across the plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within auxin import into cell IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
P-glycoprotein 21
NP_191774.2
  • P-glycoprotein 21 (PGP21); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances; INVOLVED IN: transport, transmembrane transport; LOCATED IN: plasma membrane; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ATP binding cassette subfamily B4 (TAIR:AT2G47000.1); Has 850676 Blast hits to 393228 proteins in 4171 species: Archae - 14744; Bacteria - 664075; Metazoa - 17906; Fungi - 12823; Plants - 9925; Viruses - 47; Other Eukaryotes - 131156 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    23008653..23014030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001340142.1 → NP_001327193.1  P-glycoprotein 21 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1I9LRJ8, F4IX45, Q9M1Q9
    UniProtKB/TrEMBL
    A0A178V514, A0A5S9XNQ2, A0A654FJZ1
    Conserved Domains (1) summary
    PTZ00265
    Location:16 → 1290
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  2. NM_001340143.1 → NP_001327192.1  P-glycoprotein 21 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1I9LRJ8, F4IX45, Q9M1Q9
    UniProtKB/TrEMBL
    A0A178V514, A0A5S9XNQ2, A0A654FJZ1
    Conserved Domains (1) summary
    PTZ00265
    Location:16 → 1290
    PTZ00265; multidrug resistance protein (mdr1); Provisional

  3. NM_116080.3 → NP_191774.2  P-glycoprotein 21 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191774.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1I9LRJ8, F4IX45, Q9M1Q9
    UniProtKB/TrEMBL
    A0A178V514, A0A5S9XNQ2, A0A654FJZ1
    Conserved Domains (1) summary
    PTZ00265
    Location:16 → 1290
    PTZ00265; multidrug resistance protein (mdr1); Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9M1Q9.2

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