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NEK4 NIMA-related kinase 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825503, updated on 18-Sep-2024

Summary

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Official Symbol
NEK4
Official Full Name
NIMA-related kinase 4
Primary source
TAIR:AT3G63280
Locus tag
AT3G63280
See related
Araport:AT3G63280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATNEK4; MAA21.6; NIMA-related kinase 4; NIMA-RELATED KINASE4
Summary
Encodes AtNek4, a member of the NIMA-related serine/threonine kinases (Neks) that have been linked to cell-cycle regulation in fungi and mammals. Plant Neks might be involved in plant development processes.
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Genomic context

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See NEK4 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
17
Sequence:
Chromosome: 3; NC_003074.8 (23377976..23381590)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Protein kinase superfamily protein Neighboring gene nuclease Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene FORKED 1 Neighboring gene Bax inhibitor-1 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NIMA-related kinases 6, 4, and 5 interact with each other to regulate microtubule organization during epidermal cell expansion in Arabidopsis thaliana. Motose H, et al. Plant J, 2011 Sep. PMID 21605211
  2. MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays. Popescu SC, et al. Genes Dev, 2009 Jan 1. PMID 19095804, Free PMC Article
  3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NEK6 forms heterodimers with NEK4 and NEK5 to regulate cortical microtubule organization possibly through the phosphorylation of beta-tubulins.
    Title: NIMA-related kinases 6, 4, and 5 interact with each other to regulate microtubule organization during epidermal cell expansion in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001125427.1
NM_001340197.1
NM_001340198.1
NM_116193.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
NIMA-related kinase 4
NP_001118899.1
  • NIMA-related kinase 4 (NEK4); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: NIMA-related kinase 2 (TAIR:AT3G04810.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_191887.2
  • NIMA-related kinase 4 (NEK4); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: NIMA-related kinase 2 (TAIR:AT3G04810.2); Has 126311 Blast hits to 124068 proteins in 4177 species: Archae - 117; Bacteria - 14403; Metazoa - 46720; Fungi - 12754; Plants - 30797; Viruses - 521; Other Eukaryotes - 20999 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    23377976..23381590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116193.5 → NP_191887.2  NIMA-related kinase 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191887.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RXT4, Q9M1W2
    UniProtKB/TrEMBL
    A0A7G2F030
    Conserved Domains (2) summary
    smart00220
    Location:4 → 256
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08215
    Location:3 → 258
    STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase

  2. NM_001340197.1 → NP_001326587.1  NIMA-related kinase 4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RXT4, Q9M1W2
    UniProtKB/TrEMBL
    A0A7G2F030
    Conserved Domains (2) summary
    smart00220
    Location:4 → 256
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08215
    Location:3 → 258
    STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase

  3. NM_001125427.1 → NP_001118899.1  NIMA-related kinase 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118899.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RXT4, Q9M1W2
    UniProtKB/TrEMBL
    A0A7G2F030
    Conserved Domains (2) summary
    smart00220
    Location:4 → 256
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08215
    Location:3 → 258
    STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase

  4. NM_001340198.1 → NP_001326588.1  NIMA-related kinase 4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LPR2, A0A5S9XP22, A0A654FKB1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8RXT4.1

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