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BB RING/U-box superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825528, updated on 18-Sep-2024

Summary

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Official Symbol
BB
Official Full Name
RING/U-box superfamily protein
Primary source
TAIR:AT3G63530
Locus tag
AT3G63530
See related
Araport:AT3G63530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
BB2; BIG BROTHER; ENHANCER1 OF DA1; EOD1
Summary
Encodes a novel E3 ubiquitin ligase that acts as a central negative regulator of Arabidopsis floral organ size. Organ size is limited by restricting the period of proliferative growth, rather than the rate of growth and appears to act in a novel pathway, independent of ANT and JAG. Both mRNA and protein are expressed in all actively growing regions of the plant and the vasculature and the protein is rapidly turned over by proteasome-mediated degradation.
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Genomic context

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Location:
chromosome: 3
Exon count:
9
Sequence:
Chromosome: 3; NC_003074.8 (23456055..23458732, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain protein (DUF1423) Neighboring gene ncRNA Neighboring gene FMN-linked oxidoreductases superfamily protein Neighboring gene carotenoid cleavage dioxygenase 1 Neighboring gene thylakoid lumenal protein (Mog1/PsbP/DUF1795-like photosystem II reaction center PsbP family protein)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BIG BROTHER Uncouples Cell Proliferation from Elongation in the Arabidopsis Primary Root. Cattaneo P, et al. Plant Cell Physiol, 2017 Sep 1. PMID 28922745, Free PMC Article
  2. Expression of the central growth regulator BIG BROTHER is regulated by multiple cis-elements. Breuninger H, et al. BMC Plant Biol, 2012 Mar 20. PMID 22433627, Free PMC Article
  3. Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis. Dong H, et al. Genes Dev, 2017 Jan 15. PMID 28167503, Free PMC Article
  4. Forever Young: The Role of Ubiquitin Receptor DA1 and E3 Ligase BIG BROTHER in Controlling Leaf Growth and Development. Vanhaeren H, et al. Plant Physiol, 2017 Feb. PMID 28003326, Free PMC Article
  5. The E3 ubiquitin ligase BIG BROTHER controls arabidopsis organ size in a dosage-dependent manner. Disch S, et al. Curr Biol, 2006 Feb 7. PMID 16461280

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BB acts conceptually similarly in leaf(-like) organs and the primary root, and uncouples cell proliferation from elongation in the root meristem.
    Title: BIG BROTHER Uncouples Cell Proliferation from Elongation in the Arabidopsis Primary Root.
  2. Big brother protein role in controlling leaf growth and senescence
    Title: Forever Young: The Role of Ubiquitin Receptor DA1 and E3 Ligase BIG BROTHER in Controlling Leaf Growth and Development.
  3. Genetic analyses show that DA2 functions synergistically with DA1 to regulate seed size, but does so independently of EOD1. Further results reveal that DA2 interacts physically with DA1 in vitro and in vivo.
    Title: The ubiquitin receptor DA1 interacts with the E3 ubiquitin ligase DA2 to regulate seed and organ size in Arabidopsis.
  4. Conserved cis-elements are important for regulation of BB expression.
    Title: Expression of the central growth regulator BIG BROTHER is regulated by multiple cis-elements.
  5. The E3 ubiquitin ligase BIG BROTHER controls arabidopsis organ size in a dosage-dependent manner.
    Title: The E3 ubiquitin ligase BIG BROTHER controls arabidopsis organ size in a dosage-dependent manner.
Submit: New GeneRIF Correction

General gene information

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NM_001035845.2
NM_148885.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within floral organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of leaf senescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
RING/U-box superfamily protein
NP_001030922.1
  • BIG BROTHER (BB); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT3G19910.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_680148.1
  • BIG BROTHER (BB); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT3G19910.1); Has 8059 Blast hits to 8045 proteins in 262 species: Archae - 0; Bacteria - 0; Metazoa - 2322; Fungi - 418; Plants - 4266; Viruses - 8; Other Eukaryotes - 1045 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    23456055..23458732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001035845.2 → NP_001030922.1  RING/U-box superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001030922.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0Z296, Q8L649
    UniProtKB/TrEMBL
    A0A178VG02, A0A7G2F052
    Conserved Domains (3) summary
    COG5219
    Location:156 → 241
    COG5219; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00162
    Location:197 → 237
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:197 → 237
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. NM_148885.3 → NP_680148.1  RING/U-box superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_680148.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0Z296, Q8L649
    UniProtKB/TrEMBL
    A0A178VG02, A0A7G2F052
    Conserved Domains (3) summary
    COG5219
    Location:156 → 241
    COG5219; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd00162
    Location:197 → 237
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:197 → 237
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8L649.1

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