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UPL5 ubiquitin protein ligase 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 826870, updated on 18-Sep-2024

Summary

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Official Symbol
UPL5
Official Full Name
ubiquitin protein ligase 5
Primary source
TAIR:AT4G12570
Locus tag
AT4G12570
See related
Araport:AT4G12570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
T1P17.160; T1P17_160; ubiquitin protein ligase 5
Summary
Knock-out mutants showed accelerated senescence of leaves.
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Genomic context

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See UPL5 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
3
Sequence:
Chromosome: 4; NC_003075.7 (7445278..7449205)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene uncharacterized protein Neighboring gene ER membrane protein complex subunit-like protein (Protein of unknown function DUF106, transmembrane)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A HECT E3 ubiquitin ligase negatively regulates Arabidopsis leaf senescence through degradation of the transcription factor WRKY53. Miao Y, et al. Plant J, 2010 Jul. PMID 20409006
  2. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WRKY53 is ubiquitinated by UPL5 which regulates the WRKY53-mediated leaf senescence pathway.
    Title: A HECT E3 ubiquitin ligase negatively regulates Arabidopsis leaf senescence through degradation of the transcription factor WRKY53.
Submit: New GeneRIF Correction

General gene information

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NM_117327.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within leaf senescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to jasmonic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
ubiquitin protein ligase 5
NP_192994.1
  • ubiquitin protein ligase 5 (UPL5); CONTAINS InterPro DOMAIN/s: Ubiquitin subgroup (InterPro:IPR019956), Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955), HECT (InterPro:IPR000569); BEST Arabidopsis thaliana protein match is: ubiquitin-protein ligase 1 (TAIR:AT1G55860.1); Has 13201 Blast hits to 8328 proteins in 676 species: Archae - 0; Bacteria - 15; Metazoa - 6234; Fungi - 1825; Plants - 2664; Viruses - 167; Other Eukaryotes - 2296 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    7445278..7449205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_117327.3 → NP_192994.1  ubiquitin protein ligase 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_192994.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SU29
    UniProtKB/TrEMBL
    A0A178V5H1, A0A5S9XRM7
    Conserved Domains (4) summary
    smart00119
    Location:540 → 860
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    smart00213
    Location:95 → 167
    UBQ; Ubiquitin homologues
    cd00078
    Location:511 → 871
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00240
    Location:102 → 168
    ubiquitin; Ubiquitin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SU29.1

Gene LinkOut

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