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HOG1 S-adenosyl-L-homocysteine hydrolase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827028, updated on 14-Nov-2024

Summary

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Official Symbol
HOG1
Official Full Name
S-adenosyl-L-homocysteine hydrolase
Primary source
TAIR:AT4G13940
Locus tag
AT4G13940
See related
Araport:AT4G13940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATSAHH1; DL3010W; EMB1395; EMBRYO DEFECTIVE 1395; FCAALL.35; HOMOLOGY-DEPENDENT GENE SILENCING 1; MATERNAL EFFECT EMBRYO ARREST 58; MEE58; S-ADENOSYL-L-HOMOCYSTEIN HYDROLASE 1; S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE; SAH1; SAHH1
Summary
Encodes a S-adenosyl-L-homocysteine hydrolase required for DNA methylation-dependent gene silencing.
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Genomic context

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See HOG1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
3
Sequence:
Chromosome: 4; NC_003075.7 (8054673..8057181)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene receptor like protein 50 Neighboring gene serine hydroxymethyltransferase 4 Neighboring gene ralf-like 31 Neighboring gene defensin-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene silencing and homology-dependent gene silencing in Arabidopsis: genetic modifiers and DNA methylation. Furner IJ, et al. Genetics, 1998 Jun. PMID 9611181, Free PMC Article
  2. The Arabidopsis HOMOLOGY-DEPENDENT GENE SILENCING1 gene codes for an S-adenosyl-L-homocysteine hydrolase required for DNA methylation-dependent gene silencing. Rocha PS, et al. Plant Cell, 2005 Feb. PMID 15659630, Free PMC Article
  3. Transcriptome profiling and methyl homeostasis of an Arabidopsis mutant deficient in S-adenosylhomocysteine hydrolase1 (SAHH1). Ouyang B, et al. Plant Mol Biol, 2012 Jul. PMID 22555436
  4. A histone methylation-dependent DNA methylation pathway is uniquely impaired by deficiency in Arabidopsis S-adenosylhomocysteine hydrolase. Mull L, et al. Genetics, 2006 Nov. PMID 16951055, Free PMC Article
  5. Arabidopsis HOG1 gene and its petunia homolog PETCBP act as key regulators of yield parameters. Godge MR, et al. Plant Cell Rep, 2008 Sep. PMID 18592247

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SAHH1 plays a critical role in methyl homeostasis, and its deficiency is a major contributing factor to the change of global gene expression, metabolic pathways and activation of transposable elements in the sahh1 mutant.
    Title: Transcriptome profiling and methyl homeostasis of an Arabidopsis mutant deficient in S-adenosylhomocysteine hydrolase1 (SAHH1).
  2. The nuclear targeting of ADK1 and SAHH1 is mediated by their interaction with cap MT.
    Title: Nuclear targeting of methyl-recycling enzymes in Arabidopsis thaliana is mediated by specific protein interactions.
  3. HOG1 has high affinity cytokinin binding activity. Overexpression led to early flowering with a significantly reduced plant biomass and number of leaves.
    Title: Arabidopsis HOG1 gene and its petunia homolog PETCBP act as key regulators of yield parameters.
  4. A histone methylation-dependent DNA methylation pathway is uniquely impaired by deficiency in adenosylhomocysteinase.
    Title: A histone methylation-dependent DNA methylation pathway is uniquely impaired by deficiency in Arabidopsis S-adenosylhomocysteine hydrolase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001036550.1
NM_001036551.1
NM_001084918.1
NM_117468.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables adenosylhomocysteinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables copper ion binding HDA PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA methylation-dependent constitutive heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo development ending in seed dormancy NAS
Non-traceable Author Statement
more info
  
acts_upstream_of_or_within post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in Golgi apparatus RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in plasmodesma HDA PubMed 
located_in vacuole HDA PubMed 

General protein information

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Preferred Names
S-adenosyl-L-homocysteine hydrolase
NP_001031627.1
  • HOMOLOGY-DEPENDENT GENE SILENCING 1 (HOG1); FUNCTIONS IN: adenosylhomocysteinase activity, copper ion binding; INVOLVED IN: methylation-dependent chromatin silencing, one-carbon metabolic process, posttranscriptional gene silencing, embryo development ending in seed dormancy; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 35 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: S-adenosyl-L-homocysteine hydrolase (InterPro:IPR000043), S-adenosyl-L-homocysteine hydrolase, conserved site (InterPro:IPR020082), S-adenosyl-L-homocysteine hydrolase, NAD binding (InterPro:IPR015878); BEST Arabidopsis thaliana protein match is: S-adenosyl-l-homocysteine (SAH) hydrolase 2 (TAIR:AT3G23810.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001031628.1
  • HOMOLOGY-DEPENDENT GENE SILENCING 1 (HOG1); FUNCTIONS IN: adenosylhomocysteinase activity, copper ion binding; INVOLVED IN: methylation-dependent chromatin silencing, one-carbon metabolic process, posttranscriptional gene silencing, embryo development ending in seed dormancy; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 35 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: S-adenosyl-L-homocysteine hydrolase (InterPro:IPR000043), S-adenosyl-L-homocysteine hydrolase, conserved site (InterPro:IPR020082), S-adenosyl-L-homocysteine hydrolase, NAD binding (InterPro:IPR015878); BEST Arabidopsis thaliana protein match is: S-adenosyl-l-homocysteine (SAH) hydrolase 2 (TAIR:AT3G23810.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001078387.1
  • HOMOLOGY-DEPENDENT GENE SILENCING 1 (HOG1); FUNCTIONS IN: adenosylhomocysteinase activity; INVOLVED IN: methylation-dependent chromatin silencing, one-carbon metabolic process, posttranscriptional gene silencing, embryo development ending in seed dormancy; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 34 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: S-adenosyl-L-homocysteine hydrolase (InterPro:IPR000043), S-adenosyl-L-homocysteine hydrolase, conserved site (InterPro:IPR020082), NAD(P)-binding domain (InterPro:IPR016040), S-adenosyl-L-homocysteine hydrolase, NAD binding (InterPro:IPR015878); BEST Arabidopsis thaliana protein match is: S-adenosyl-l-homocysteine (SAH) hydrolase 2 (TAIR:AT3G23810.1); Has 6788 Blast hits to 6786 proteins in 1444 species: Archae - 223; Bacteria - 2243; Metazoa - 514; Fungi - 135; Plants - 203; Viruses - 0; Other Eukaryotes - 3470 (source: NCBI BLink).
NP_193130.1
  • MATERNAL EFFECT EMBRYO ARREST 58 (MEE58); FUNCTIONS IN: adenosylhomocysteinase activity, copper ion binding; INVOLVED IN: methylation-dependent chromatin silencing, one-carbon metabolic process, posttranscriptional gene silencing, embryo development ending in seed dormancy; LOCATED IN: plasma membrane, vacuole, membrane; EXPRESSED IN: 36 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: S-adenosyl-L-homocysteine hydrolase, conserved site (InterPro:IPR020082), S-adenosyl-L-homocysteine hydrolase (InterPro:IPR000043), S-adenosyl-L-homocysteine hydrolase, NAD binding (InterPro:IPR015878); BEST Arabidopsis thaliana protein match is: S-adenosyl-l-homocysteine (SAH) hydrolase 2 (TAIR:AT3G23810.1); Has 7964 Blast hits to 7958 proteins in 1477 species: Archae - 229; Bacteria - 2334; Metazoa - 639; Fungi - 145; Plants - 247; Viruses - 0; Other Eukaryotes - 4370 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    8054673..8057181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_117468.3 → NP_193130.1  S-adenosyl-L-homocysteine hydrolase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_193130.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23255, O81847, Q8LE20
    UniProtKB/TrEMBL
    A0A178UZR5, A0A5S9XS27, Q5D6C3, Q5D6C4, Q5D6C5
    Conserved Domains (1) summary
    PLN02494
    Location:9 → 485
    PLN02494; adenosylhomocysteinase

  2. NM_001084918.1 → NP_001078387.1  S-adenosyl-L-homocysteine hydrolase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078387.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8MQP1, B9DG03
    Conserved Domains (1) summary
    cl21454
    Location:13 → 308
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. NM_001036551.1 → NP_001031628.1  S-adenosyl-L-homocysteine hydrolase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031628.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4JTV4, Q5D6C3, Q5D6C4, Q5D6C5
    Conserved Domains (2) summary
    PLN02494
    Location:9 → 440
    PLN02494; adenosylhomocysteinase
    pfam05221
    Location:13 → 439
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase

  4. NM_001036550.1 → NP_001031627.1  S-adenosyl-L-homocysteine hydrolase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031627.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4JTV5
    Conserved Domains (1) summary
    cl21454
    Location:2 → 363
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O23255.1

Gene LinkOut

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