MES16 methyl esterase 16 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MES16
Official Full Name: methyl esterase 16
Primary source: TAIR:AT4G16690
Locus tag: AT4G16690
See related: Araport:AT4G16690
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA METHYL ESTERASE 16; ATMES16; DL4370C; FCAALL.12; methyl esterase 16
Summary: Encodes a protein shown to have carboxylesterase activity, methyl IAA esterase activity, and methyl jasmonate esterase activity in vitro. This protein does not act on MeSA, MeGA4, or MEGA9 in vitro. Although MES16 is similar to MES17, a MeIAA hydrolase, two mes16 mutant lines (SALK_151578) and (SALK_139756) do not show altered sensitivity to MeIAA in root growth assays. MES16 transcripts appear to be more than 10-fold less abundant than those of MES17 in roots.
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Genomic context

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See MES16 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 3

Sequence:: Chromosome: 4; NC_003075.7 (9391964..9393650, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our biochemical studies reveal that MES16 has esterase activity with methyl-indole acetic acid as the substrate, and the catalytically essential role of Ser-87 has been demonstrated.
Title: Crystal structure of methylesterase family member 16 (MES16) from Arabidopsis thaliana.
data demonstrate that MES16 is an integral component of Chl breakdown in Arabidopsis and specifically demethylates Chl catabolites at the level of FCCs in the cytosol
Title: MES16, a member of the methylesterase protein family, specifically demethylates fluorescent chlorophyll catabolites during chlorophyll breakdown in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_117770.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables hydrolase activity, acting on ester bonds	IDA Inferred from Direct Assay more info	PubMed
enables methyl indole-3-acetate esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables methyl jasmonate esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables methyl jasmonate esterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chlorophyll catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oxylipin biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: methyl esterase 16

NP_193402.1

methyl esterase 16 (MES16); FUNCTIONS IN: hydrolase activity, acting on ester bonds, methyl jasmonate esterase activity, catalytic activity, methyl indole-3-acetate esterase activity; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: methyl esterase 18 (TAIR:AT5G58310.1); Has 1277 Blast hits to 1277 proteins in 292 species: Archae - 4; Bacteria - 558; Metazoa - 0; Fungi - 14; Plants - 596; Viruses - 3; Other Eukaryotes - 102 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

9391964..9393650 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117770.5 → NP_193402.1 methyl esterase 16 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O23512

UniProtKB/TrEMBL

A0A654FQ46

Conserved Domains (2) summary

PLN02965
Location:8 → 262

PLN02965; Probable pheophorbidase

PLN02211
Location:12 → 256

PLN02211; methyl indole-3-acetate methyltransferase