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HSF1 heat shock factor 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827496, updated on 18-Sep-2024

Summary

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Official Symbol
HSF1
Official Full Name
heat shock factor 1
Primary source
TAIR:AT4G17750
Locus tag
AT4G17750
See related
Araport:AT4G17750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA CLASS A HEAT SHOCK FACTOR 1A; ARABIDOPSIS THALIANA HEAT SHOCK FACTOR 1; ATHSF1; ATHSFA1A; CLASS A HEAT SHOCK FACTOR 1A; DL4910C; FCAALL.107; HEAT SHOCK FACTOR; heat shock factor 1; HSFA1A
Summary
native protein is a trimer, interacts with HSP70, also with TBP, DNA interaction is modulated by phosphorylation and is heat-shock inducible
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Genomic context

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See HSF1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
2
Sequence:
Chromosome: 4; NC_003075.7 (9869818..9871646, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene syntaxin of plants 23 Neighboring gene Peptidase S41 family protein Neighboring gene PCNA domain-containing protein Neighboring gene tRNA-Trp

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of Arabidopsis HsfA1a enhances diverse stress tolerance by promoting stress-induced Hsp expression. Qian J, et al. Genet Mol Res, 2014 Feb 27. PMID 24634180
  2. Arabidopsis heat shock factor: isolation and characterization of the gene and the recombinant protein. Hübel A, et al. Plant Mol Biol, 1994 Oct. PMID 7948881
  3. Transcription factor BES1 interacts with HSFA1 to promote heat stress resistance of plants. Albertos P, et al. EMBO J, 2022 Feb 1. PMID 34981847, Free PMC Article
  4. Arabidopsis HsfA1 transcription factors function as the main positive regulators in heat shock-responsive gene expression. Yoshida T, et al. Mol Genet Genomics, 2011 Dec. PMID 21931939
  5. AtHSBP functions in seed development and the motif is required for subcellular localization and interaction with AtHSFs. Hsu SF, et al. Plant Signal Behav, 2010 Aug. PMID 20657173, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcription factor BES1 interacts with HSFA1 to promote heat stress resistance of plants.
    Title: Transcription factor BES1 interacts with HSFA1 to promote heat stress resistance of plants.
  2. Results revealed that overexpressing HsfA1a had positive effects on tolerance to diverse stressors by promoting inducible Hsp expression following stress-induced HsfA1a activation.
    Title: Overexpression of Arabidopsis HsfA1a enhances diverse stress tolerance by promoting stress-induced Hsp expression.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

NM_117884.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
heat shock factor 1
NP_193510.1
  • heat shock factor 1 (HSF1); CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Heat shock factor (HSF)-type, DNA-binding (InterPro:IPR000232); BEST Arabidopsis thaliana protein match is: heat shock transcription factor A1D (TAIR:AT1G32330.1); Has 101009 Blast hits to 12266 proteins in 352 species: Archae - 60; Bacteria - 127; Metazoa - 1552; Fungi - 3291; Plants - 964; Viruses - 2; Other Eukaryotes - 95013 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    9869818..9871646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_117884.3 → NP_193510.1  heat shock factor 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_193510.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23615, P41151, Q0WNT9
    UniProtKB/TrEMBL
    A0A178UWX9
    Conserved Domains (1) summary
    smart00415
    Location:50 → 142
    HSF; heat shock factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41151.2

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