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BSK3 BR-signaling kinase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828025, updated on 18-Sep-2024

Summary

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Official Symbol
BSK3
Official Full Name
BR-signaling kinase 3
Primary source
TAIR:AT4G00710
Locus tag
AT4G00710
See related
Araport:AT4G00710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
BR-signaling kinase 3; brassinosteroid-signaling kinase 3; F6N23.9; F6N23_9
Summary
Encodes BR-signaling kinase 3 (BSK3), one of the three homologous BR-signaling kinases (BSK1, AT4G35230; BSK2, AT5G46570; BSK3, AT4G00710). Mediates signal transduction from receptor kinase BRI1 by functioning as the substrate of BRI1. Plasma membrane localized.
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Genomic context

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See BSK3 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
11
Sequence:
Chromosome: 4; NC_003075.7 (289779..293492)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene UB-like protease 1B Neighboring gene ncRNA Neighboring gene Spc97/Spc98 family of spindle pole body (SBP) component Neighboring gene C2 calcium/lipid-binding plant phosphoribosyltransferase family protein Neighboring gene shaggy-like protein kinase 32 Neighboring gene Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Natural variation of BSK3 tunes brassinosteroid signaling to regulate root foraging under low nitrogen. Jia Z, et al. Nat Commun, 2019 May 30. PMID 31147541, Free PMC Article
  2. BRASSINOSTEROID-SIGNALING KINASE 3, a plasma membrane-associated scaffold protein involved in early brassinosteroid signaling. Ren H, et al. PLoS Genet, 2019 Jan. PMID 30615605, Free PMC Article
  3. BSKs mediate signal transduction from the receptor kinase BRI1 in Arabidopsis. Tang W, et al. Science, 2008 Jul 25. PMID 18653891, Free PMC Article
  4. Shade-induced RTFL/DVL peptides negatively regulate the shade response by directly interacting with BSKs in Arabidopsis. Huang S, et al. Nat Commun, 2023 Oct 28. PMID 37898648, Free PMC Article
  5. BSKs are partially redundant positive regulators of brassinosteroid signaling in Arabidopsis. Sreeramulu S, et al. Plant J, 2013 Jun. PMID 23496207

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BSK3 modulates root elongation under mild nitrogen deficiency. In particular, a proline to leucine substitution in the predicted kinase domain of BSK3 enhances brassinosteroid sensitivity and signaling to increase the extent of root elongation.
    Title: Natural variation of BSK3 tunes brassinosteroid signaling to regulate root foraging under low nitrogen.
  2. we find that BSK3 upregulates BSU1 transcript and protein levels to activate BR signaling. BSK3 is broadly expressed and plays an important role in BR-mediated root growth, shoot growth, and organ separation. Together, our findings suggest that BSK3 may function as a scaffold protein to regulate BR signaling. The results of our studies provide new insights into early BR signaling mechanisms.
    Title: BRASSINOSTEROID-SIGNALING KINASE 3, a plasma membrane-associated scaffold protein involved in early brassinosteroid signaling.
  3. BSK3 interacts with multiple receptor-like kinases in Arabidopsis.
    Title: A brassinosteroid-signaling kinase interacts with multiple receptor-like kinases in Arabidopsis.
  4. 3 homologous brassinosteroid (BR)-signaling kinases (BSK1, BSK2 & BSK3)were identified; the BSKs are phosphorylated by BRI1; results demonstrate that BSKs are the substrates of BRI1 kinase that activate downstream BR signal transduction. [BSK3]
    Title: BSKs mediate signal transduction from the receptor kinase BRI1 in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001340265.1
NM_116296.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brassinosteroid mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in brassinosteroid mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
BR-signaling kinase 3
NP_191980.2
  • BR-signaling kinase 3 (BSK3); FUNCTIONS IN: binding, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: brassinosteroid mediated signaling pathway, N-terminal protein myristoylation; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Protein kinase, catalytic domain (InterPro:IPR000719), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase protein with tetratricopeptide repeat domain (TAIR:AT1G01740.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    289779..293492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116296.4 → NP_191980.2  BR-signaling kinase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191980.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O65280, Q8W4L3
    UniProtKB/TrEMBL
    A0A178V3B2, A0A7G2EV77
    Conserved Domains (2) summary
    sd00006
    Location:385 → 409
    TPR; TPR repeat [structural motif]
    cl21453
    Location:72 → 312
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001340265.1 → NP_001329175.1  BR-signaling kinase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O65280, Q8W4L3
    UniProtKB/TrEMBL
    A0A178V3B2, A0A7G2EV77
    Conserved Domains (2) summary
    sd00006
    Location:385 → 409
    TPR; TPR repeat [structural motif]
    cl21453
    Location:72 → 312
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8W4L3.1

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