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PRL Minichromosome maintenance (MCM2/3/5) family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828153, updated on 18-Sep-2024

Summary

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Official Symbol
PRL
Official Full Name
Minichromosome maintenance (MCM2/3/5) family protein
Primary source
TAIR:AT4G02060
Locus tag
AT4G02060
See related
Araport:AT4G02060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MCM7; PROLIFERA; T10M13.7; T10M13_7
Summary
Member of the minichromosome maintenance complex, involved in DNA replication initiation. Abundant in proliferating and endocycling tissues. Localized in the nucleus during G1, S and G2 phases of the cell cycle, and are released into the cytoplasmic compartment during mitosis. Binds chromatin.
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Genomic context

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See PRL in Genome Data Viewer
Location:
chromosome: 4
Exon count:
17
Sequence:
Chromosome: 4; NC_003075.7 (900636..905591)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Vps51/Vps67 family (components of vesicular transport) protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene sugar transporter protein 7 Neighboring gene tRNA-His Neighboring gene MUTS homolog 6 Neighboring gene RING/FYVE/PHD zinc finger superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The essential Mcm7 protein PROLIFERA is localized to the nucleus of dividing cells during the G(1) phase and is required maternally for early Arabidopsis development. Springer PS, et al. Development, 2000 May. PMID 10751170
  2. BICELLULAR POLLEN 1 is a modulator of DNA replication and pollen development in Arabidopsis. Long YP, et al. New Phytol, 2019 Apr. PMID 30484867
  3. Dynamic localization of the DNA replication proteins MCM5 and MCM7 in plants. Shultz RW, et al. Plant Physiol, 2009 Jun. PMID 19357199, Free PMC Article
  4. The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1. Takahashi N, et al. EMBO J, 2008 Jul 9. PMID 18528439, Free PMC Article
  5. Sugar and hormone connections. León P, et al. Trends Plant Sci, 2003 Mar. PMID 12663220

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

NM_001203726.1
NM_116437.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA unwinding involved in DNA replication TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated DNA replication IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within sugar mediated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
  
part_of THO complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Minichromosome maintenance (MCM2/3/5) family protein
NP_001190655.1
  • PROLIFERA (PRL); CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), ATPase, AAA+ type, core (InterPro:IPR003593), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 7 (InterPro:IPR008050); BEST Arabidopsis thaliana protein match is: minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT5G44635.1).
NP_192115.1
  • PROLIFERA (PRL); FUNCTIONS IN: protein binding, DNA-dependent ATPase activity, DNA binding, ATP binding; INVOLVED IN: sugar mediated signaling pathway, cell proliferation, DNA-dependent DNA replication initiation, DNA unwinding involved in replication; LOCATED IN: nuclear chromatin, nucleus, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), ATPase, AAA+ type, core (InterPro:IPR003593), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 7 (InterPro:IPR008050); BEST Arabidopsis thaliana protein match is: minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT5G44635.1); Has 4609 Blast hits to 4442 proteins in 796 species: Archae - 407; Bacteria - 660; Metazoa - 1239; Fungi - 945; Plants - 433; Viruses - 2; Other Eukaryotes - 923 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    900636..905591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001203726.1 → NP_001190655.1  Minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190655.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04721, P43299
    UniProtKB/TrEMBL
    A0A178V048, A0A5S9XP27, A0A654FL69
    Conserved Domains (2) summary
    smart00350
    Location:139 → 638
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:16 → 98
    MCM_N; MCM N-terminal domain

  2. NM_116437.3 → NP_192115.1  Minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_192115.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04721, P43299
    UniProtKB/TrEMBL
    A0A178V048, A0A5S9XP27, A0A654FL69
    Conserved Domains (2) summary
    smart00350
    Location:139 → 638
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:16 → 98
    MCM_N; MCM N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43299.2

Gene LinkOut

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