U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DIR6 Disease resistance-responsive (dirigent-like protein) family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828469, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
DIR6
Official Full Name
Disease resistance-responsive (dirigent-like protein) family protein
Primary source
TAIR:AT4G23690
Locus tag
AT4G23690
See related
Araport:AT4G23690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Arabidopsis thaliana dirigent protein 6; AtDIR6; dirigent protein 6; F9D16.160; F9D16_160
Summary
Encodes a homodimeric all-beta dirigent protein in the superfamily of calycins. Dirigent proteins impart stereoselectivity on the phenoxy radical coupling reaction yielding optically active lignans from two molecules of coniferyl alcohol.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See DIR6 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
1
Sequence:
Chromosome: 4; NC_003075.7 (12338829..12339967, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein Neighboring gene cation/H+ exchanger 17 Neighboring gene vacuolar ATP synthase subunit G2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Optimized expression of the dirigent protein AtDIR6 in Pichia pastoris and impact of glycosylation on protein structure and function. Kazenwadel C, et al. Appl Microbiol Biotechnol, 2013 Aug. PMID 23188459
  2. A model of dirigent proteins derived from structural and functional similarities with allene oxide cyclase and lipocalins. Pickel B, et al. FEBS J, 2012 Jun. PMID 22443713
  3. An enantiocomplementary dirigent protein for the enantioselective laccase-catalyzed oxidative coupling of phenols. Pickel B, et al. Angew Chem Int Ed Engl, 2010. PMID 19946920
  4. Opposite stereoselectivities of dirigent proteins in Arabidopsis and schizandra species. Kim KW, et al. J Biol Chem, 2012 Oct 5. PMID 22854967, Free PMC Article
  5. Dirigent Protein Mode of Action Revealed by the Crystal Structure of AtDIR6. Gasper R, et al. Plant Physiol, 2016 Dec. PMID 27756822, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

NM_118500.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables guiding stereospecific synthesis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within (-)-pinoresinol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in (-)-pinoresinol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region ISM
Inferred from Sequence Model
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Disease resistance-responsive (dirigent-like protein) family protein
NP_194100.1
  • Disease resistance-responsive (dirigent-like protein) family protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: lignan biosynthetic process, defense response; LOCATED IN: endomembrane system; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Plant disease resistance response protein (InterPro:IPR004265); BEST Arabidopsis thaliana protein match is: Disease resistance-responsive (dirigent-like protein) family protein (TAIR:AT1G64160.1); Has 772 Blast hits to 771 proteins in 42 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 772; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    12338829..12339967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_118500.3 → NP_194100.1  Disease resistance-responsive (dirigent-like protein) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_194100.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SUQ8
    UniProtKB/TrEMBL
    A0A178UWA1, A0A5S9XVU9, A0A654FS52
    Conserved Domains (1) summary
    pfam03018
    Location:41 → 183
    Dirigent; Dirigent-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SUQ8.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools