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MC2 metacaspase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828614, updated on 18-Sep-2024

Summary

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Official Symbol
MC2
Official Full Name
metacaspase 2
Primary source
TAIR:AT4G25110
Locus tag
AT4G25110
See related
Araport:AT4G25110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtMC2; AtMCP1c; F24A6.7; MCP1c; metacaspase 1c; metacaspase 2
Summary
Encodes a type I metacaspase. Two Arabidopsis metacaspases, AT1G02170 (MC1) and AT4G25110 (MC2) antagonistically control programmed cell death in Arabidopsis. MC1 is a positive regulator of cell death and requires conserved caspase-like putative catalytic residues for its function. MC2 negatively regulates cell death. This function is independent of the putative catalytic residues. A third type I Arabidopsis metacaspase is MC3 (AT5g64240).
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Genomic context

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See MC2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
5
Sequence:
Chromosome: 4; NC_003075.7 (12887474..12890262, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene magnesium-protoporphyrin IX methyltransferase Neighboring gene Riboflavin synthase-like superfamily protein Neighboring gene Fe superoxide dismutase 1 Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene peptide met sulfoxide reductase 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The prodomain of Arabidopsis metacaspase 2 positively regulates immune signaling mediated by pattern-recognition receptors. Wu D, et al. New Phytol, 2024 Jan. PMID 37920109
  2. Arabidopsis type I metacaspases control cell death. Coll NS, et al. Science, 2010 Dec 3. PMID 21097903
  3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

General gene information

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Homology

NM_001036634.1
NM_118643.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
metacaspase 2
NP_001031711.1
  • metacaspase 2 (MC2); FUNCTIONS IN: cysteine-type endopeptidase activity; INVOLVED IN: proteolysis; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, LSD1-type (InterPro:IPR005735), Peptidase C14, caspase catalytic (InterPro:IPR011600); BEST Arabidopsis thaliana protein match is: metacaspase 1 (TAIR:AT1G02170.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_194241.3
  • metacaspase 2 (MC2); FUNCTIONS IN: cysteine-type endopeptidase activity; INVOLVED IN: proteolysis; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C14, caspase catalytic (InterPro:IPR011600), Zinc finger, LSD1-type (InterPro:IPR005735); BEST Arabidopsis thaliana protein match is: metacaspase 1 (TAIR:AT1G02170.1); Has 7673 Blast hits to 3913 proteins in 538 species: Archae - 9; Bacteria - 793; Metazoa - 961; Fungi - 920; Plants - 3202; Viruses - 585; Other Eukaryotes - 1203 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    12887474..12890262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_118643.5 → NP_194241.3  metacaspase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_194241.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q682S4, Q7XJE5, Q9SW15
    UniProtKB/TrEMBL
    A0A178V2G1, A0A5S9XVM7
    Conserved Domains (2) summary
    TIGR01053
    Location:4 → 34
    LSD1; zinc finger domain, LSD1 subclass
    pfam00656
    Location:116 → 352
    Peptidase_C14; Caspase domain

  2. NM_001036634.1 → NP_001031711.1  metacaspase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031711.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7XJE5
    Conserved Domains (2) summary
    TIGR01053
    Location:4 → 34
    LSD1; zinc finger domain, LSD1 subclass
    pfam00656
    Location:116 → 349
    Peptidase_C14; Caspase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7XJE5.1

Gene LinkOut

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