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ATR2 P450 reductase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829144, updated on 18-Sep-2024

Summary

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Official Symbol
ATR2
Official Full Name
P450 reductase 2
Primary source
TAIR:AT4G30210
Locus tag
AT4G30210
See related
Araport:AT4G30210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AR2; F9N11.60; F9N11_60; P450 reductase 2
Summary
Encodes NADPH-cytochrome P450 reductase that catalyzes the first oxidative step of the phenylpropanoid general pathway.
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Genomic context

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See ATR2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
17
Sequence:
Chromosome: 4; NC_003075.7 (14796695..14800961)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene H[+]-ATPase 2 Neighboring gene vernalization5/VIN3-like protein Neighboring gene small nuclear ribonucleoprotein F Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the Arabidopsis thaliana NADPH-cytochrome P450 reductase 2 (ATR2) provides insight into its function. Niu G, et al. FEBS J, 2017 Mar. PMID 28103421
  2. Mutation of the inducible ARABIDOPSIS THALIANA CYTOCHROME P450 REDUCTASE2 alters lignin composition and improves saccharification. Sundin L, et al. Plant Physiol, 2014 Dec. PMID 25315601, Free PMC Article
  3. Bacterial expression and purification of the Arabidopsis NADPH-cytochrome P450 reductase ATR2. Hull AK, et al. Protein Expr Purif, 2000 Apr. PMID 10733884
  4. Two isoforms of NADPH:cytochrome P450 reductase in Arabidopsis thaliana. Gene structure, heterologous expression in insect cells, and differential regulation. Mizutani M, et al. Plant Physiol, 1998 Jan. PMID 9449848, Free PMC Article
  5. Cloning, yeast expression, and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-cytochrome P450 reductases with P450 CYP73A5. Urban P, et al. J Biol Chem, 1997 Aug 1. PMID 9235908

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

NM_119167.4
NM_179141.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables NADPH-hemoprotein reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADPH-hemoprotein reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phenylpropanoid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phenylpropanoid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
P450 reductase 2
NP_194750.1
  • P450 reductase 2 (ATR2); FUNCTIONS IN: NADPH-hemoprotein reductase activity; INVOLVED IN: phenylpropanoid metabolic process; LOCATED IN: endoplasmic reticulum, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Flavodoxin/nitric oxide synthase (InterPro:IPR008254), Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), FAD-binding, type 1 (InterPro:IPR003097), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709), NADPH Cytochrome P450 Reductase (InterPro:IPR015702); BEST Arabidopsis thaliana protein match is: P450 reductase 1 (TAIR:AT4G24520.1); Has 6728 Blast hits to 6356 proteins in 1574 species: Archae - 5; Bacteria - 3354; Metazoa - 1038; Fungi - 894; Plants - 570; Viruses - 0; Other Eukaryotes - 867 (source: NCBI BLink).
NP_849472.2
  • P450 reductase 2 (ATR2); FUNCTIONS IN: NADPH-hemoprotein reductase activity; INVOLVED IN: phenylpropanoid metabolic process; LOCATED IN: endoplasmic reticulum, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), FAD-binding, type 1 (InterPro:IPR003097), Flavodoxin/nitric oxide synthase (InterPro:IPR008254), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709); BEST Arabidopsis thaliana protein match is: P450 reductase 1 (TAIR:AT4G24520.1); Has 6811 Blast hits to 6438 proteins in 1585 species: Archae - 5; Bacteria - 3394; Metazoa - 1038; Fungi - 872; Plants - 570; Viruses - 0; Other Eukaryotes - 932 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    14796695..14800961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001342001.1 → NP_001328167.1  P450 reductase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B3S1, A0A654FU66

  2. NM_119167.4 → NP_194750.1  P450 reductase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_194750.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4JPK2, Q39036, Q9SUM3
    UniProtKB/TrEMBL
    A0A178USJ1, A0A5S9XZE6, A0A654FU66
    Conserved Domains (2) summary
    cd06204
    Location:308 → 711
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    pfam00258
    Location:107 → 250
    Flavodoxin_1

  3. NM_179141.2 → NP_849472.2  P450 reductase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849472.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FU66
    Conserved Domains (3) summary
    cd06204
    Location:308 → 712
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    COG0369
    Location:103 → 712
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:107 → 250
    Flavodoxin_1; Flavodoxin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SUM3.1

Gene LinkOut

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