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nPAP nuclear poly(a) polymerase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829421, updated on 18-Sep-2024

Summary

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Official Symbol
nPAP
Official Full Name
nuclear poly(a) polymerase
Primary source
TAIR:AT4G32850
Locus tag
AT4G32850
See related
Araport:AT4G32850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
nuclear poly(a) polymerase; PAP(IV); PAPS4; poly(A) polymerase 4; poly(A) polymerase IV
Summary
Encodes a nuclear poly(A) polymerase. Located in the nucleus.
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Genomic context

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See nPAP in Genome Data Viewer
Location:
chromosome: 4
Exon count:
12
Sequence:
Chromosome: 4; NC_003075.7 (15849711..15855194)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene carotenoid cleavage dioxygenase 8 Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ataurora1 Neighboring gene phosphofructokinase 6 Neighboring gene Avr9/Cf-9 rapidly elicited protein Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Target specificity among canonical nuclear poly(A) polymerases in plants modulates organ growth and pathogen response. Vi SL, et al. Proc Natl Acad Sci U S A, 2013 Aug 20. PMID 23918356, Free PMC Article
  2. An interaction between an Arabidopsis poly(A) polymerase and a homologue of the 100 kDa subunit of CPSF. Elliott BJ, et al. Plant Mol Biol, 2003 Feb. PMID 12602868
  3. Characterization of genes encoding poly(A) polymerases in plants: evidence for duplication and functional specialization. Meeks LR, et al. PLoS One, 2009 Nov 26. PMID 19956626, Free PMC Article
  4. Novel alternative splicing of mRNAs encoding poly(A) polymerases in Arabidopsis. Addepalli B, et al. Biochim Biophys Acta, 2004 Aug 12. PMID 15297145
  5. An Arabidopsis Fip1 homolog interacts with RNA and provides conceptual links with a number of other polyadenylation factor subunits. Forbes KP, et al. J Biol Chem, 2006 Jan 6. PMID 16282318

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The relative activities of canonical nuclear PAPS isoforms control de novo synthesized poly(A) tail length and hence expression of specific subsets of mRNAs.
    Title: Target specificity among canonical nuclear poly(A) polymerases in plants modulates organ growth and pathogen response.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001036701.1
NM_001036702.1
NM_001125630.1
NM_001125631.2
NM_001342179.1
NM_001342180.1
NM_001342181.1
NM_001342182.1
NM_001342183.1
NM_001342184.1
NM_001342185.1
NM_119438.4
NM_179230.2
NM_179231.2
NM_202939.3
NM_202940.3
NM_202941.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
nuclear poly(a) polymerase
NP_001031778.1
  • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001031779.1
  • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001119102.1
  • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_001119103.1
  • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_195011.4
  • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 808 Blast hits to 801 proteins in 219 species: Archae - 0; Bacteria - 13; Metazoa - 260; Fungi - 212; Plants - 185; Viruses - 0; Other Eukaryotes - 138 (source: NCBI BLink).
NP_849561.1
  • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 808 Blast hits to 801 proteins in 219 species: Archae - 0; Bacteria - 13; Metazoa - 260; Fungi - 212; Plants - 185; Viruses - 0; Other Eukaryotes - 138 (source: NCBI BLink).
NP_849562.2
  • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_974668.1
  • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_974669.1
  • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_974670.2
  • nuclear poly(a) polymerase (nPAP); CONTAINS InterPro DOMAIN/s: Poly(A) polymerase (InterPro:IPR014492), Nucleotidyltransferase, class I, C-terminal-like (InterPro:IPR011068), Poly(A) polymerase, central domain (InterPro:IPR007012), Nucleotidyl transferase domain (InterPro:IPR002934), Poly(A) polymerase, RNA-binding domain (InterPro:IPR007010); Has 808 Blast hits to 801 proteins in 219 species: Archae - 0; Bacteria - 13; Metazoa - 260; Fungi - 212; Plants - 185; Viruses - 0; Other Eukaryotes - 138 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    15849711..15855194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_202939.3 → NP_974668.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974668.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UV15
    Conserved Domains (2) summary
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  2. NM_001342180.1 → NP_001329664.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UV15
    Conserved Domains (2) summary
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  3. NM_001342182.1 → NP_001329669.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UV15
    Conserved Domains (2) summary
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  4. NM_001342181.1 → NP_001329663.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UV15
    Conserved Domains (2) summary
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  5. NM_001342179.1 → NP_001329665.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UV15
    Conserved Domains (2) summary
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  6. NM_001125631.2 → NP_001119103.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001119103.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UUT9, A0A7G2F7M2
    Conserved Domains (2) summary
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  7. NM_202940.3 → NP_974669.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974669.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2F2N9
    Conserved Domains (2) summary
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  8. NM_179230.2 → NP_849561.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849561.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3H654, B9DFE4, F4JV63, F4JV67, F4JV69, F4JV71, F4JV72, Q0WLA9, Q7XJ91, Q8VYW1, Q9M075
    UniProtKB/TrEMBL
    A0A7G2F7M2
    Conserved Domains (2) summary
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  9. NM_202941.3 → NP_974670.2  nuclear poly(a) polymerase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974670.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2F2N9
    Conserved Domains (2) summary
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  10. NM_001342183.1 → NP_001329668.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UV15
    Conserved Domains (2) summary
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  11. NM_001342184.1 → NP_001329667.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UV15
    Conserved Domains (2) summary
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  12. NM_001342185.1 → NP_001329666.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UV15
    Conserved Domains (2) summary
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  13. NM_001036702.1 → NP_001031779.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031779.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2F7M2
    Conserved Domains (3) summary
    COG5186
    Location:15 → 505
    PAP1; Poly(A) polymerase Pap1 [RNA processing and modification]
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  14. NM_001036701.1 → NP_001031778.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031778.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UV15
    Conserved Domains (3) summary
    COG5186
    Location:15 → 505
    PAP1; Poly(A) polymerase Pap1 [RNA processing and modification]
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  15. NM_179231.2 → NP_849562.2  nuclear poly(a) polymerase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849562.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2F2N9
    Conserved Domains (2) summary
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  16. NM_119438.4 → NP_195011.4  nuclear poly(a) polymerase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195011.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2F2N9
    Conserved Domains (3) summary
    COG5186
    Location:15 → 505
    PAP1; Poly(A) polymerase Pap1 [RNA processing and modification]
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain

  17. NM_001125630.1 → NP_001119102.1  nuclear poly(a) polymerase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001119102.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2F2N9
    Conserved Domains (2) summary
    pfam04926
    Location:369 → 501
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 365
    PAP_central; Poly(A) polymerase central domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VYW1.1

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