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KCS18 3-ketoacyl-CoA synthase 18 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829603, updated on 18-Sep-2024

Summary

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Official Symbol
KCS18
Official Full Name
3-ketoacyl-CoA synthase 18
Primary source
TAIR:AT4G34520
Locus tag
AT4G34520
See related
Araport:AT4G34520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
3-ketoacyl-CoA synthase 18; FAE1; FATTY ACID ELONGATION1; T4L20.100; T4L20_100
Summary
Encodes KCS18, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
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Genomic context

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See KCS18 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
1
Sequence:
Chromosome: 4; NC_003075.7 (16494205..16495842)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene 3-ketoacyl-CoA synthase 17 Neighboring gene NmrA-like negative transcriptional regulator family protein Neighboring gene cryptochrome-interacting basic-helix-loop-helix 1 Neighboring gene F-box protein Neighboring gene Ribosomal protein S25 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Natural variation in seed very long chain fatty acid content is controlled by a new isoform of KCS18 in Arabidopsis thaliana. Jasinski S, et al. PLoS One, 2012. PMID 23145136, Free PMC Article
  2. Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis epidermis induces cell death and suggests a critical role for phospholipase A2 in this process. Reina-Pinto JJ, et al. Plant Cell, 2009 Apr. PMID 19376931, Free PMC Article
  3. Active-site residues of a plant membrane-bound fatty acid elongase beta-ketoacyl-CoA synthase, FAE1 KCS. Ghanevati M, et al. Biochim Biophys Acta, 2001 Jan 15. PMID 11341960
  4. Design of a Seed-Specific Chimeric Promoter with a Modified Expression Profile to Improve Seed Oil Content. Aoyagi T, et al. Int J Mol Sci, 2018 Jun 5. PMID 29874815, Free PMC Article
  5. Directed tagging of the Arabidopsis FATTY ACID ELONGATION1 (FAE1) gene with the maize transposon activator. James DW Jr, et al. Plant Cell, 1995 Mar. PMID 7734965, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We constructed a chimeric promoter that starts to express in the early stage of seed development, and high-level expression is retained until the later stage by connecting the promoters of the biotin carboxyl carrier protein 2 (BCCP2) gene encoding the BCCP2 subunit of acetyl-CoA carboxylase and the fatty acid elongase 1 (FAE1) gene from Arabidopsis
    Title: Design of a Seed-Specific Chimeric Promoter with a Modified Expression Profile to Improve Seed Oil Content.
  2. KCS18 is a major control point for very long chain fatty acid synthesis in Arabidopsis.
    Title: Natural variation in seed very long chain fatty acid content is controlled by a new isoform of KCS18 in Arabidopsis thaliana.
  3. Nuclei of arrested trichome cells in FAE1 misexpression plants cell-autonomously accumulate high levels of DNA damage, including double-strand breaks characteristic of lipoapoptosis.
    Title: Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis epidermis induces cell death and suggests a critical role for phospholipase A2 in this process.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_119617.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables fatty acid elongase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within very long-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-ketoacyl-CoA synthase 18
NP_195178.1
  • 3-ketoacyl-CoA synthase 18 (KCS18); FUNCTIONS IN: fatty acid elongase activity, acyltransferase activity; INVOLVED IN: fatty acid elongation, very long-chain fatty acid metabolic process; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: shoot apex, stem, fruit, carpel; EXPRESSED DURING: petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Thiolase-like (InterPro:IPR016039), Very-long-chain 3-ketoacyl-CoA synthase (InterPro:IPR012392), 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal (InterPro:IPR013747), FAE1/Type III polyketide synthase-like protein (InterPro:IPR013601), Thiolase-like, subgroup (InterPro:IPR016038); BEST Arabidopsis thaliana protein match is: 3-ketoacyl-CoA synthase 9 (TAIR:AT2G16280.1); Has 5011 Blast hits to 4998 proteins in 1240 species: Archae - 0; Bacteria - 1718; Metazoa - 0; Fungi - 14; Plants - 3124; Viruses - 0; Other Eukaryotes - 155 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    16494205..16495842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119617.2 → NP_195178.1  3-ketoacyl-CoA synthase 18 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195178.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q38860
    UniProtKB/TrEMBL
    A0A178UUK5, A0A5S9XYM9, A0A654FVH3
    Conserved Domains (1) summary
    PLN02932
    Location:10 → 491
    PLN02932; 3-ketoacyl-CoA synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q38860.1

Gene LinkOut

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