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ADC2 arginine decarboxylase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829623, updated on 18-Sep-2024

Summary

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Official Symbol
ADC2
Official Full Name
arginine decarboxylase 2
Primary source
TAIR:AT4G34710
Locus tag
AT4G34710
See related
Araport:AT4G34710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARGININE DECARBOXYLASE; arginine decarboxylase 2; ATADC2; SPE2; T4L20.290; T4L20_290
Summary
encodes a arginine decarboxylase (ADC), a rate-limiting enzyme that catalyzes the first step of polyamine (PA) biosynthesis via ADC pathway in Arabidopsis thaliana. Arabidopsis genome has two ADC paralogs, ADC1 and ADC2. ADC2 is stress-inducible (osmotic stress). Double mutant analysis showed that ADC genes are essential for the production of PA, and are required for normal seed development. Overexpression causes phenotypes similar to GA-deficient plants and these plants show reduced levels of GA due to lower expression levels of AtGA20ox1, AtGA3ox3 and AtGA3ox1.
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Genomic context

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See ADC2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
1
Sequence:
Chromosome: 4; NC_003075.7 (16560030..16563044, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene LYR family of Fe/S cluster biogenesis protein Neighboring gene ncRNA Neighboring gene ATPase, F0/V0 complex, subunit C protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Putrescine accumulation confers drought tolerance in transgenic Arabidopsis plants over-expressing the homologous Arginine decarboxylase 2 gene. Alcázar R, et al. Plant Physiol Biochem, 2010 Jul. PMID 20206537
  2. Induction of the arginine decarboxylase ADC2 gene provides evidence for the involvement of polyamines in the wound response in Arabidopsis. Perez-Amador MA, et al. Plant Physiol, 2002 Nov. PMID 12428010, Free PMC Article
  3. Arabidopsis knockout mutation of ADC2 gene reveals inducibility by osmotic stress. Soyka S, et al. FEBS Lett, 1999 Sep 17. PMID 10481069
  4. Hetero- and homodimerization of Arabidopsis thaliana arginine decarboxylase AtADC1 and AtADC2. Maruri-López I, et al. Biochem Biophys Res Commun, 2017 Mar 11. PMID 28109885
  5. Simultaneous Silencing of Two Arginine Decarboxylase Genes Alters Development in Arabidopsis. Sánchez-Rangel D, et al. Front Plant Sci, 2016. PMID 27014322, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study reveals that both ADC proteins are located in the same cell compartments, and they are able to form protein interaction complexes with each other.
    Title: Hetero- and homodimerization of Arabidopsis thaliana arginine decarboxylase AtADC1 and AtADC2.
  2. ADC2 had a major contribution of to total arginine decarboxylase (ADC) activity and the specific induction of ADC1 in response to infection.
    Title: Role of Arginine decarboxylase (ADC) in Arabidopsis thaliana defence against the pathogenic bacterium Pseudomonas viridiflava.
  3. a reduction in transpiration rate and stomata conductance was observed in the ADC2 over-expressor lines.
    Title: Putrescine accumulation confers drought tolerance in transgenic Arabidopsis plants over-expressing the homologous Arginine decarboxylase 2 gene.
  4. Arginine decarboxylase genes are required for production of polyamines that are essential for normal seed development in Arabidopsis
    Title: Arabidopsis ADC genes involved in polyamine biosynthesis are essential for seed development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_119637.3
NM_202955.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables arginine decarboxylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in arginine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within polyamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within putrescine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to jasmonic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within seed development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
arginine decarboxylase 2
NP_195197.1
  • arginine decarboxylase 2 (ADC2); CONTAINS InterPro DOMAIN/s: Orn/DAP/Arg decarboxylase 2, C-terminal (InterPro:IPR022643), Orn/DAP/Arg decarboxylase 2, conserved site (InterPro:IPR022657), Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site (InterPro:IPR022653), Ornithine/DAP/Arg decarboxylase (InterPro:IPR000183), Arginine decarboxylase (InterPro:IPR002985), Orn/DAP/Arg decarboxylase 2, N-terminal (InterPro:IPR022644); BEST Arabidopsis thaliana protein match is: arginine decarboxylase 1 (TAIR:AT2G16500.1); Has 7853 Blast hits to 7777 proteins in 2122 species: Archae - 112; Bacteria - 5255; Metazoa - 102; Fungi - 32; Plants - 645; Viruses - 2; Other Eukaryotes - 1705 (source: NCBI BLink).
NP_974684.1
  • arginine decarboxylase 2 (ADC2); CONTAINS InterPro DOMAIN/s: Orn/DAP/Arg decarboxylase 2, C-terminal (InterPro:IPR022643), Orn/DAP/Arg decarboxylase 2, conserved site (InterPro:IPR022657), Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site (InterPro:IPR022653), Ornithine/DAP/Arg decarboxylase (InterPro:IPR000183), Arginine decarboxylase (InterPro:IPR002985), Orn/DAP/Arg decarboxylase 2, N-terminal (InterPro:IPR022644); BEST Arabidopsis thaliana protein match is: arginine decarboxylase 1 (TAIR:AT2G16500.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    16560030..16563044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119637.3 → NP_195197.1  arginine decarboxylase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195197.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23141, Q8H165, Q93ZG4
    UniProtKB/TrEMBL
    A0A178V3H1, A0A5S9XYQ1, A0A654FVJ1
    Conserved Domains (1) summary
    PLN02439
    Location:108 → 680
    PLN02439; arginine decarboxylase

  2. NM_202955.1 → NP_974684.1  arginine decarboxylase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974684.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23141, Q8H165, Q93ZG4
    UniProtKB/TrEMBL
    A0A178V3H1, A0A5S9XYQ1, A0A654FVJ1
    Conserved Domains (1) summary
    PLN02439
    Location:108 → 680
    PLN02439; arginine decarboxylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O23141.1

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