RecQl3 DEAD/DEAH box RNA helicase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RecQl3
Official Full Name: DEAD/DEAH box RNA helicase family protein
Primary source: TAIR:AT4G35740
Locus tag: AT4G35740
See related: Araport:AT4G35740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: A. THALIANA RECQ HELICASE 3; ATRECQ3; F8D20.250; F8D20_250
Summary: Encodes RECQ3, an ATP-dependent helicase.
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Genomic context

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See RecQl3 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 19

Sequence:: Chromosome: 4; NC_003075.7 (16935988..16940372)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The DNA unwinding of RecQ helicases from Arabidopsis thaliana, AtRECQ2 and AtRECQ3 at the single-molecule level using magnetic tweezers, is reported
Title: Fork sensing and strand switching control antagonistic activities of RecQ helicases.
AtRECQ2 and AtRECQ3 differ in their requirements for (deoxy)nucleoside triphosphates for strand unwinding and in processing of Holliday junctions.
Title: Biochemical characterization of AtRECQ3 reveals significant differences relative to other RecQ helicases.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_119740.3

Supported by ESTs:

NM_179169.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables four-way junction helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables helicase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA duplex unwinding	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA recombination	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: DEAD/DEAH box RNA helicase family protein

NP_195299.2

RecQl3; FUNCTIONS IN: ATP binding, ATP-dependent helicase activity; INVOLVED IN: DNA recombination; LOCATED IN: cellular_component unknown; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), DNA helicase, ATP-dependent, RecQ type (InterPro:IPR004589), DNA helicase, ATP-dependent, RecQ type, N-terminal (InterPro:IPR018329), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: RECQ helicase L2 (TAIR:AT1G31360.1); Has 32322 Blast hits to 32243 proteins in 2865 species: Archae - 544; Bacteria - 19123; Metazoa - 3830; Fungi - 3081; Plants - 1743; Viruses - 10; Other Eukaryotes - 3991 (source: NCBI BLink).

NP_849500.1

RecQl3; FUNCTIONS IN: ATP binding, ATP-dependent helicase activity; INVOLVED IN: DNA recombination; LOCATED IN: cellular_component unknown; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), DNA helicase, ATP-dependent, RecQ type (InterPro:IPR004589), DNA helicase, ATP-dependent, RecQ type, N-terminal (InterPro:IPR018329), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: RECQ helicase L2 (TAIR:AT1G31360.1); Has 28158 Blast hits to 28089 proteins in 2765 species: Archae - 286; Bacteria - 16813; Metazoa - 3341; Fungi - 2669; Plants - 1491; Viruses - 10; Other Eukaryotes - 3548 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

16935988..16940372

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119740.3 → NP_195299.2 DEAD/DEAH box RNA helicase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195299.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WPC1, Q3E9Q7, Q9FT72

UniProtKB/TrEMBL

A0A5S9XZM7

Conserved Domains (4) summary

smart00487
Location:32 → 235

DEXDc; DEAD-like helicases superfamily

cd00079
Location:229 → 359

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam00270
Location:41 → 207

DEAD; DEAD/DEAH box helicase

pfam16124
Location:364 → 427

RecQ_Zn_bind; RecQ zinc-binding
NM_179169.1 → NP_849500.1 DEAD/DEAH box RNA helicase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849500.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XZM7

Conserved Domains (4) summary

COG0514
Location:1 → 337

RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]

cd00079
Location:136 → 266

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam16124
Location:271 → 334

RecQ_Zn_bind; RecQ zinc-binding

cl21455
Location:36 → 114

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases