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VAB2 ATPase, V1 complex, subunit B protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830008, updated on 18-Sep-2024

Summary

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Official Symbol
VAB2
Official Full Name
ATPase, V1 complex, subunit B protein
Primary source
TAIR:AT4G38510
Locus tag
AT4G38510
See related
Araport:AT4G38510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtVAB2; F22I13.8; V-ATPase B subunit 2; VHA-B2
Summary
One of three genes encoding the vacuolar ATP synthase subunit B1. The protein binds to and co-localizes with F-actin, bundles F-actin to form higher-order structure, and stabilizes actin filaments in vitro.
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Genomic context

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See VAB2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
16
Sequence:
Chromosome: 4; NC_003075.7 (18010812..18015173, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene chromatin-remodeling complex subunit Neighboring gene Sept9 (DUF616) Neighboring gene Protein phosphatase 2C family protein Neighboring gene phospholipase C1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphatidylinositol 3-Kinase Promotes Activation and Vacuolar Acidification and Delays Methyl Jasmonate-Induced Leaf Senescence. Liu J, et al. Plant Physiol, 2016 Mar. PMID 26739232, Free PMC Article
  2. Arabidopsis vacuolar H+-ATPase (V-ATPase) B subunits are involved in actin cytoskeleton remodeling via binding to, bundling, and stabilizing F-actin. Ma B, et al. J Biol Chem, 2012 Jun 1. PMID 22371505, Free PMC Article
  3. SOS2 promotes salt tolerance in part by interacting with the vacuolar H+-ATPase and upregulating its transport activity. Batelli G, et al. Mol Cell Biol, 2007 Nov. PMID 17875927, Free PMC Article
  4. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502
  5. Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana. Ferro M, et al. Mol Cell Proteomics, 2003 May. PMID 12766230

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001036730.2
NM_001036731.2
NM_001204025.1
NM_120012.4
NM_202978.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within actin filament bundle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within actin filament capping IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of actin filament depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in chloroplast envelope HDA PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  
part_of proton-transporting V-type ATPase, V1 domain IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole HDA PubMed 

General protein information

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Preferred Names
ATPase, V1 complex, subunit B protein
NP_001031807.1
  • ATPase, V1 complex, subunit B protein; FUNCTIONS IN: hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, ATP binding, proton-transporting ATPase activity, rotational mechanism; INVOLVED IN: proton transport, ATP metabolic process, ATP synthesis coupled proton transport; LOCATED IN: plasma membrane, vacuole, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, alpha/beta subunit, nucleotide-binding domain, active site (InterPro:IPR020003), ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal (InterPro:IPR000793), ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal (InterPro:IPR004100), ATPase, alpha/beta subunit, nucleotide-binding domain (InterPro:IPR000194), ATPase, V1 complex, subunit B (InterPro:IPR005723); BEST Arabidopsis thaliana protein match is: ATPase, V1 complex, subunit B protein (TAIR:AT1G76030.1); Has 40414 Blast hits to 39266 proteins in 9675 species: Archae - 969; Bacteria - 20976; Metazoa - 1668; Fungi - 811; Plants - 8180; Viruses - 0; Other Eukaryotes - 7810 (source: NCBI BLink).
NP_001031808.1
  • ATPase, V1 complex, subunit B protein; FUNCTIONS IN: hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, ATP binding, proton-transporting ATPase activity, rotational mechanism; INVOLVED IN: proton transport, ATP metabolic process, ATP synthesis coupled proton transport; LOCATED IN: plasma membrane, vacuole, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, alpha/beta subunit, nucleotide-binding domain, active site (InterPro:IPR020003), ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal (InterPro:IPR000793), ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal (InterPro:IPR004100), ATPase, alpha/beta subunit, nucleotide-binding domain (InterPro:IPR000194), ATPase, V1 complex, subunit B (InterPro:IPR005723); BEST Arabidopsis thaliana protein match is: ATPase, V1 complex, subunit B protein (TAIR:AT1G76030.1); Has 40414 Blast hits to 39266 proteins in 9675 species: Archae - 969; Bacteria - 20976; Metazoa - 1668; Fungi - 811; Plants - 8180; Viruses - 0; Other Eukaryotes - 7810 (source: NCBI BLink).
NP_001190954.1
  • ATPase, V1 complex, subunit B protein; FUNCTIONS IN: hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, ATP binding, proton-transporting ATPase activity, rotational mechanism; INVOLVED IN: proton transport, ATP metabolic process, ATP synthesis coupled proton transport; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal (InterPro:IPR000793), ATPase, alpha/beta subunit, nucleotide-binding domain, active site (InterPro:IPR020003), ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal (InterPro:IPR004100), ATPase, alpha/beta subunit, nucleotide-binding domain (InterPro:IPR000194), ATPase, V1 complex, subunit B (InterPro:IPR005723); BEST Arabidopsis thaliana protein match is: ATPase, V1 complex, subunit B protein (TAIR:AT1G76030.1).
NP_195563.1
  • ATPase, V1 complex, subunit B protein; FUNCTIONS IN: hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, proton-transporting ATPase activity, rotational mechanism, ATP binding; INVOLVED IN: proton transport, ATP metabolic process, ATP synthesis coupled proton transport; LOCATED IN: plasma membrane, vacuole, membrane, chloroplast envelope; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, alpha/beta subunit, nucleotide-binding domain, active site (InterPro:IPR020003), ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal (InterPro:IPR000793), ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal (InterPro:IPR004100), ATPase, alpha/beta subunit, nucleotide-binding domain (InterPro:IPR000194), ATPase, V1 complex, subunit B (InterPro:IPR005723); BEST Arabidopsis thaliana protein match is: ATPase, V1 complex, subunit B protein (TAIR:AT1G76030.1); Has 40414 Blast hits to 39266 proteins in 9675 species: Archae - 969; Bacteria - 20976; Metazoa - 1668; Fungi - 811; Plants - 8180; Viruses - 0; Other Eukaryotes - 7810 (source: NCBI BLink).
NP_974707.1
  • ATPase, V1 complex, subunit B protein; FUNCTIONS IN: hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, ATP binding, proton-transporting ATPase activity, rotational mechanism; INVOLVED IN: proton transport, ATP metabolic process, ATP synthesis coupled proton transport; LOCATED IN: plasma membrane, vacuole, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, alpha/beta subunit, nucleotide-binding domain, active site (InterPro:IPR020003), ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal (InterPro:IPR000793), ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal (InterPro:IPR004100), ATPase, alpha/beta subunit, nucleotide-binding domain (InterPro:IPR000194), ATPase, V1 complex, subunit B (InterPro:IPR005723); BEST Arabidopsis thaliana protein match is: ATPase, V1 complex, subunit B protein (TAIR:AT1G76030.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    18010812..18015173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_202978.2 → NP_974707.1  ATPase, V1 complex, subunit B protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974707.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DGU0, B9DHP3, Q56W88, Q94AY7, Q9SZN1
    UniProtKB/TrEMBL
    A0A178V0N0, A0A5S9XZS3, A0A7G2F713
    Conserved Domains (1) summary
    TIGR01040
    Location:19 → 484
    V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit

  2. NM_001036730.2 → NP_001031807.1  ATPase, V1 complex, subunit B protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031807.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DGU0, B9DHP3, Q56W88, Q94AY7, Q9SZN1
    UniProtKB/TrEMBL
    A0A178V0N0, A0A5S9XZS3, A0A7G2F713
    Conserved Domains (1) summary
    TIGR01040
    Location:19 → 484
    V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit

  3. NM_001036731.2 → NP_001031808.1  ATPase, V1 complex, subunit B protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031808.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DGU0, B9DHP3, Q56W88, Q94AY7, Q9SZN1
    UniProtKB/TrEMBL
    A0A178V0N0, A0A5S9XZS3, A0A7G2F713
    Conserved Domains (1) summary
    TIGR01040
    Location:19 → 484
    V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit

  4. NM_120012.4 → NP_195563.1  ATPase, V1 complex, subunit B protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195563.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DGU0, B9DHP3, Q56W88, Q94AY7, Q9SZN1
    UniProtKB/TrEMBL
    A0A178V0N0, A0A5S9XZS3, A0A7G2F713
    Conserved Domains (1) summary
    TIGR01040
    Location:19 → 484
    V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit

  5. NM_001204025.1 → NP_001190954.1  ATPase, V1 complex, subunit B protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190954.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2F713, F4JTQ0
    Conserved Domains (4) summary
    cd01135
    Location:98 → 385
    V_A-ATPase_B; V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi ...
    TIGR01040
    Location:26 → 491
    V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit
    pfam00306
    Location:401 → 492
    ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
    pfam02874
    Location:30 → 96
    ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SZN1.1

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