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ASA1 anthranilate synthase alpha subunit 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830457, updated on 18-Sep-2024

Summary

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Official Symbol
ASA1
Official Full Name
anthranilate synthase alpha subunit 1
Primary source
TAIR:AT5G05730
Locus tag
AT5G05730
See related
Araport:AT5G05730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
A-METHYL TRYPTOPHAN RESISTANT 1; AMT1; ANTHRANILATE SYNTHASE ALPHA SUBUNIT; anthranilate synthase alpha subunit 1; JASMONATE-INDUCED DEFECTIVE LATERAL ROOT 1; JDL1; MJJ3.14; MJJ3_14; TRP5; TRYPTOPHAN BIOSYNTHESIS 5; WEAK ETHYLENE INSENSITIVE 2; WEI2
Summary
ASA1 encodes the alpha subunit of anthranilate synthase, which catalyzes the rate-limiting step of tryptophan synthesis. ASA1 is induced by ethylene, and forms a link between ethylene signalling and auxin synthesis in roots.
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Genomic context

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See ASA1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Sequence:
Chromosome: 5; NC_003076.8 (1719533..1722933, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene arginine-tRNA protein transferase 1 Neighboring gene Pleckstrin homology (PH) domain superfamily protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene uncharacterized protein Neighboring gene ethylene-dependent gravitropism-deficient and yellow-green-like 2 Neighboring gene DNAJ heat shock N-terminal domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional expression of Arabidopsis thaliana anthranilate synthase subunit I in Escherichia coli. Bernasconi P, et al. Plant Physiol, 1994 Sep. PMID 7972519, Free PMC Article
  2. The Arabidopsis thaliana trp5 mutant has a feedback-resistant anthranilate synthase and elevated soluble tryptophan. Li J, et al. Plant Physiol, 1996 Jan. PMID 8587994, Free PMC Article
  3. Molecular basis of alpha-methyltryptophan resistance in amt-1, a mutant of Arabidopsis thaliana with altered tryptophan metabolism. Kreps JA, et al. Plant Physiol, 1996 Apr. PMID 8934623, Free PMC Article
  4. Arabidopsis ASA1 is important for jasmonate-mediated regulation of auxin biosynthesis and transport during lateral root formation. Sun J, et al. Plant Cell, 2009 May. PMID 19435934, Free PMC Article
  5. Pore mutations in ammonium transporter AMT1 with increased electrogenic ammonium transport activity. Loqué D, et al. J Biol Chem, 2009 Sep 11. PMID 19581303, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A transcription factor STOP1-centered pathway coordinates ammonium and phosphate acquisition in Arabidopsis.
    Title: A transcription factor STOP1-centered pathway coordinates ammonium and phosphate acquisition in Arabidopsis.
  2. indole-3-butyric acid induced adventitious root-formation by conversion into Indole-3-acetic acid (IAA) involving nitric oxide activity, and by a positive action on IAA-transport and ASA1/ASB1-mediated IAA-biosynthesis
    Title: Indole-3-butyric acid promotes adventitious rooting in Arabidopsis thaliana thin cell layers by conversion into indole-3-acetic acid and stimulation of anthranilate synthase activity.
  3. In BnaA.TTG2.a.1-overexpressing Arabidopsis under salt stress, the endogenous indole-3-acetic acid content was reduced, and expression of two auxin biosynthesis genes, TRYPTOPHAN BIOSYNTHESIS 5 (TRP5) and YUCCA2 (YUC2), was downregulated.
    Title: Expression of Brassica napus TTG2, a regulator of trichome development, increases plant sensitivity to salt stress by suppressing the expression of auxin biosynthesis genes.
  4. Using loss- and gain-of-function transgenic lines as well as biochemical analysis, we demonstrate that ERF1 can directly up-regulate ASA1 by binding to its promoter, leading to auxin accumulation and ethylene-induced inhibition of root growth.
    Title: Arabidopsis ERF1 Mediates Cross-Talk between Ethylene and Auxin Biosynthesis during Primary Root Elongation by Regulating ASA1 Expression.
  5. Mutations of ASA1 and the TIR1/AFBs auxin receptor genes impair the inhibitory effect of 5 muM MeJA on PIN2 endocytosis and enhance the reduction effect of 50 muM MeJA on the plasma membrane accumulation of PIN2.
    Title: Jasmonate modulates endocytosis and plasma membrane accumulation of the Arabidopsis PIN2 protein.
  6. Pore mutations in ammonium transporter AMT1 may have a role in increased electrogenic ammonium transport activity
    Title: Pore mutations in ammonium transporter AMT1 with increased electrogenic ammonium transport activity.
  7. ASA1 has a role in jasmonate-induced auxin biosynthesis.
    Title: Arabidopsis ASA1 is important for jasmonate-mediated regulation of auxin biosynthesis and transport during lateral root formation.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001203302.1
NM_120655.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables anthranilate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables anthranilate synthase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables anthranilate synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within auxin biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lateral root formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of auxin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to ethylene IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in tryptophan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tryptophan biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of anthranilate synthase complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast TAS
Traceable Author Statement
more info
 PubMed 
located_in chloroplast stroma HDA PubMed 

General protein information

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Preferred Names
anthranilate synthase alpha subunit 1
NP_001190231.1
  • anthranilate synthase alpha subunit 1 (ASA1); CONTAINS InterPro DOMAIN/s: Anthranilate synthase component I, N-terminal (InterPro:IPR006805), Chorismate binding, C-terminal (InterPro:IPR015890), ADC synthase (InterPro:IPR005801), Anthranilate synthase component I (InterPro:IPR019999), Anthranilate synthase component I, PabB-like (InterPro:IPR005256); BEST Arabidopsis thaliana protein match is: anthranilate synthase 2 (TAIR:AT2G29690.1).
NP_196192.1
  • anthranilate synthase alpha subunit 1 (ASA1); FUNCTIONS IN: anthranilate synthase activity; INVOLVED IN: in 6 processes; LOCATED IN: chloroplast, anthranilate synthase complex; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Anthranilate synthase component I, N-terminal (InterPro:IPR006805), Chorismate binding, C-terminal (InterPro:IPR015890), ADC synthase (InterPro:IPR005801), Anthranilate synthase component I (InterPro:IPR019999), Anthranilate synthase component I, PabB-like (InterPro:IPR005256); BEST Arabidopsis thaliana protein match is: anthranilate synthase 2 (TAIR:AT2G29690.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    1719533..1722933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120655.4 → NP_196192.1  anthranilate synthase alpha subunit 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196192.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32068
    UniProtKB/TrEMBL
    A0A178UPV8, A0A5S9Y1Q1
    Conserved Domains (3) summary
    PLN02445
    Location:72 → 594
    PLN02445; anthranilate synthase component I
    pfam00425
    Location:307 → 577
    Chorismate_bind; chorismate binding enzyme
    pfam04715
    Location:89 → 245
    Anth_synt_I_N; Anthranilate synthase component I, N terminal region

  2. NM_001203302.1 → NP_001190231.1  anthranilate synthase alpha subunit 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190231.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UPV8, A0A5S9Y1Q1, F4K0T5
    Conserved Domains (3) summary
    PLN02445
    Location:72 → 623
    PLN02445; anthranilate synthase component I
    pfam00425
    Location:307 → 606
    Chorismate_bind; chorismate binding enzyme
    pfam04715
    Location:89 → 245
    Anth_synt_I_N; Anthranilate synthase component I, N terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32068.1

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