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ATXR5 TRITHORAX-RELATED PROTEIN 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830839, updated on 18-Sep-2024

Summary

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Official Symbol
ATXR5
Official Full Name
TRITHORAX-RELATED PROTEIN 5
Primary source
TAIR:AT5G09790
Locus tag
AT5G09790
See related
Araport:AT5G09790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5; F17I14.20; F17I14_20; PDE336; PIGMENT DEFECTIVE 336; SDG15; SETDOMAIN GROUP 15
Summary
Encodes a SET-domain protein, a H3K27 monomethyltransferases required for chromatin structure and gene silencing. Regulates heterochromatic DNA replication. Contains a PCNA-binding domain. ATXR5 accumulates preferentially during the late G1 or S phase, suggesting that it plays a role in cell-cycle regulation or progression. A plant line expressing an RNAi construct directed against this gene has reduced agrobacterium-mediated tumor formation.
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Genomic context

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See ATXR5 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Sequence:
Chromosome: 5; NC_003076.8 (3038978..3041206, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L17 family protein Neighboring gene Transcriptional factor B3 family protein Neighboring gene miscRNA Neighboring gene ARM repeat superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular basis for the methylation specificity of ATXR5 for histone H3. Bergamin E, et al. Nucleic Acids Res, 2017 Jun 20. PMID 28383693, Free PMC Article
  2. ATXR5/6 Forms Alternative Protein Complexes with PCNA and the Nucleosome Core Particle. Davarinejad H, et al. J Mol Biol, 2019 Mar 29. PMID 30826376
  3. Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication. Jacob Y, et al. Science, 2014 Mar 14. PMID 24626927, Free PMC Article
  4. Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Jacob Y, et al. Nature, 2010 Aug 19. PMID 20631708, Free PMC Article
  5. ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. Jacob Y, et al. Nat Struct Mol Biol, 2009 Jul. PMID 19503079, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATXR5/6 Forms Alternative Protein Complexes with PCNA and the Nucleosome Core Particle.
    Title: ATXR5/6 Forms Alternative Protein Complexes with PCNA and the Nucleosome Core Particle.
  2. Several molecular determinants regulate ATXR5/6 methyltransferase activity and epigenetic inheritance of H3.1 K27me1 mark in plants.
    Title: Molecular basis for the methylation specificity of ATXR5 for histone H3.
  3. this study identifies a histone-modifying enzyme ATXR5 that selectively methylates the replication-dependent histone H3 variant H3.1.
    Title: Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication.
  4. mutations in the homologous histone 3 lysine 27 (H3K27) monomethyltransferases, ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and ATXR6, lead to re-replication of specific genomic locations
    Title: Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases.
  5. These results indicate that ATXR5 and ATXR6 form a new class of H3K27 methyltransferases and that H3K27me1 represents a previously uncharacterized pathway required for transcriptional repression in Arabidopsis.
    Title: ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing.
  6. ATXR5 and ARXR6 interact with proliferating cell nuclear antigen (PCNA) and are associated with a role in the cell cycle or DNA replication. [ATXR5]
    Title: Two cell-cycle regulated SET-domain proteins interact with proliferating cell nuclear antigen (PCNA) in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001085090.2
NM_001343068.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables histone H3K27 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K27 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-mediated transformation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA replication IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of cell cycle IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
TRITHORAX-RELATED PROTEIN 5
NP_001078559.1
  • ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5); CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, PHD-type (InterPro:IPR001965), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: ARABIDOPSIS TRITHORAX-RELATED PROTEIN 6 (TAIR:AT5G24330.1); Has 4395 Blast hits to 4055 proteins in 218 species: Archae - 0; Bacteria - 10; Metazoa - 2832; Fungi - 365; Plants - 935; Viruses - 0; Other Eukaryotes - 253 (source: NCBI BLink).
NP_001318519.1
  • ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5); CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, PHD-type (InterPro:IPR001965), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: ARABIDOPSIS TRITHORAX-RELATED PROTEIN 6 (TAIR:AT5G24330.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    3038978..3041206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001343068.1 → NP_001318519.1  TRITHORAX-RELATED PROTEIN 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UCN4, A0A2H1ZE68, A0A384LP05, A0A7G2FBH1
    Conserved Domains (2) summary
    cd10539
    Location:241 → 378
    SET_ATXR5_6-like; SET domain found in fungal protein lysine methyltransferase SET5 and similar protein
    cl22851
    Location:66 → 111
    PHD_SF; PHD finger superfamily

  2. NM_001085090.2 → NP_001078559.1  TRITHORAX-RELATED PROTEIN 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4KFB9, Q1AJM5, Q8VZJ1, Q9FXW6, Q9LXE2
    UniProtKB/TrEMBL
    A0A178UEL1, A0A7G2FBH1
    Conserved Domains (2) summary
    cd10539
    Location:242 → 379
    SET_ATXR5_6-like; SET domain found in fungal protein lysine methyltransferase SET5 and similar protein
    cl22851
    Location:66 → 111
    PHD_SF; PHD finger superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VZJ1.2

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