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PAS2 Protein-tyrosine phosphatase-like, PTPLA [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830912, updated on 18-Sep-2024

Summary

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Official Symbol
PAS2
Official Full Name
Protein-tyrosine phosphatase-like, PTPLA
Primary source
TAIR:AT5G10480
Locus tag
AT5G10480
See related
Araport:AT5G10480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F12B17.170; F12B17_170; PASTICCINO 2; PEP; PEPINO
Summary
Protein tyrosine phosphatase-like involved in cell division and differentiation. Interacts with CDKA;1 only in its phosphorylated form, preventing dephosphorylation. Overexpression slowed down cell division in suspension cell cultures at the G2-to-M transition and early mitosis and inhibited Arabidopsis seedling growth. Localized in the cytoplasm of dividing cells but moved into the nucleus upon cell differentiation. Based on complementation of yeast mutant PAS2 has acyl-CoA dehydratase activity. It interacts with CER10, a component of the microsomal fatty acid elongase complex, suggesting a role in synthesis of VLCFAs (very long chain fatty acids).
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Genomic context

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See PAS2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
10
Sequence:
Chromosome: 5; NC_003076.8 (3297804..3300165, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene kinesin like protein for actin based chloroplast movement 1 Neighboring gene MSCS-like 2 Neighboring gene Kinase interacting (KIP1-like) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Sos-recruitment system as a tool to analyze cellular localization of plant proteins: membrane localization of Arabidopsis thaliana PEPINO/PASTICCINO2. Schönhofer-Merl S, et al. Mol Genet Genomics, 2010 May. PMID 20300944
  2. The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development. Bach L, et al. Proc Natl Acad Sci U S A, 2008 Sep 23. PMID 18799749, Free PMC Article
  3. Pasticcino2 is a protein tyrosine phosphatase-like involved in cell proliferation and differentiation in Arabidopsis. Bellec Y, et al. Plant J, 2002 Dec. PMID 12472687
  4. The PASTICCINO genes of Arabidopsis thaliana are involved in the control of cell division and differentiation. Faure JD, et al. Development, 1998 Mar. PMID 9449673
  5. Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase A. Da Costa M, et al. Plant Cell, 2006 Jun. PMID 16698944, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PEP/PAS2 is an integral membrane protein with cytosolic N- and C-termini.
    Title: The Sos-recruitment system as a tool to analyze cellular localization of plant proteins: membrane localization of Arabidopsis thaliana PEPINO/PASTICCINO2.
  2. 3-hydroxy-acyl-CoA dehydratase PASTICCINO2 is an essential and limiting enzyme in VLCFA synthesis but also that PAS2-derived VLCFA homeostasis is required for specific developmental processes
    Title: The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development.
  3. The balance between cell division and differentiation is regulated through the interaction between CDKA;1 and the antiphosphatase PAS2.
    Title: Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase A.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001085097.1
NM_001203348.1
NM_121086.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydratase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of developmental growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within very long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
part_of fatty acid elongase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Protein-tyrosine phosphatase-like, PTPLA
NP_001078566.1
  • PASTICCINO 2 (PAS2); FUNCTIONS IN: protein tyrosine phosphatase activity, enoyl-CoA hydratase activity; INVOLVED IN: cell differentiation, negative regulation of peptidyl-tyrosine phosphorylation, regulation of cell division, negative regulation of developmental growth; LOCATED IN: cytosol, integral to membrane, nucleus, fatty acid elongase complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase-like, PTPLA (InterPro:IPR007482); BEST Arabidopsis thaliana protein match is: Protein-tyrosine phosphatase-like, PTPLA (TAIR:AT5G59770.1); Has 727 Blast hits to 727 proteins in 205 species: Archae - 0; Bacteria - 0; Metazoa - 341; Fungi - 179; Plants - 124; Viruses - 0; Other Eukaryotes - 83 (source: NCBI BLink).
NP_001190277.1
  • PASTICCINO 2 (PAS2); CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase-like, PTPLA (InterPro:IPR007482); BEST Arabidopsis thaliana protein match is: Protein-tyrosine phosphatase-like, PTPLA (TAIR:AT5G59770.1).
NP_196610.2
  • PASTICCINO 2 (PAS2); CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase-like, PTPLA (InterPro:IPR007482); BEST Arabidopsis thaliana protein match is: Protein-tyrosine phosphatase-like, PTPLA (TAIR:AT5G59770.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    3297804..3300165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121086.5 → NP_196610.2  Protein-tyrosine phosphatase-like, PTPLA [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196610.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MQH5, Q8VZB2, Q9LXA0
    UniProtKB/TrEMBL
    A0A654FZY2
    Conserved Domains (1) summary
    PLN02838
    Location:1 → 221
    PLN02838; 3-hydroxyacyl-CoA dehydratase subunit of elongase

  2. NM_001085097.1 → NP_001078566.1  Protein-tyrosine phosphatase-like, PTPLA [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078566.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9Y304
    Conserved Domains (1) summary
    PLN02838
    Location:1 → 196
    PLN02838; 3-hydroxyacyl-CoA dehydratase subunit of elongase

  3. NM_001203348.1 → NP_001190277.1  Protein-tyrosine phosphatase-like, PTPLA [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190277.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FZY2, F4KGW0
    Conserved Domains (1) summary
    PLN02838
    Location:1 → 230
    PLN02838; 3-hydroxyacyl-CoA dehydratase subunit of elongase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VZB2.1

Gene LinkOut

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