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DOT2 SART-1 family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831541, updated on 18-Sep-2024

Summary

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Official Symbol
DOT2
Official Full Name
SART-1 family
Primary source
TAIR:AT5G16780
Locus tag
AT5G16780
See related
Araport:AT5G16780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
DEFECTIVELY ORGANIZED TRIBUTARIES 2; DEFECTIVELY ORGANIZED TRIBUTARIES 2; F5E19.120; F5E19_120; MDF; MERISTEM-DEFECTIVE
Summary
Encodes a protein belonging to SART-1 family. The gene is expressed in the basal region of the developing embryo during heart stage. Phenotypic analyses of dot2 mutants suggest that this protein plays a role in root, shoot, and flower development. dot2 mutants are dwarved plants that display an aberrant spurred leaf venation pattern and fail to flower. In the roots DOT2 appears to be require for normal meristem organization and maintenance and the proper expression of PIN and PLT genes.
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Genomic context

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See DOT2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
15
Sequence:
Chromosome: 5; NC_003076.8 (5515707..5522261, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Transducin family protein / WD-40 repeat family protein Neighboring gene Inositol 1,3,4-trisphosphate 5/6-kinase family protein Neighboring gene myb domain protein 9 Neighboring gene Tho complex subunit 7/Mft1p Neighboring gene Acyl-CoA N-acyltransferases (NAT) superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MDF is a conserved splicing factor and modulates cell division and stress response in Arabidopsis. de Luxán-Hernández C, et al. Life Sci Alliance, 2023 Jan. PMID 36265897, Free PMC Article
  2. MERISTEM-DEFECTIVE, an RS domain protein, is required for the correct meristem patterning and function in Arabidopsis. Casson SA, et al. Plant J, 2009 Mar. PMID 19000164
  3. Vein patterning screens and the defectively organized tributaries mutants in Arabidopsis thaliana. Petricka JJ, et al. Plant J, 2008 Oct. PMID 18643975
  4. Interactomics of Qa-SNARE in Arabidopsis thaliana. Fujiwara M, et al. Plant Cell Physiol, 2014 Apr. PMID 24556609
  5. Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions. Pendle AF, et al. Mol Biol Cell, 2005 Jan. PMID 15496452, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MDF is a conserved splicing factor and modulates cell division and stress response in Arabidopsis.
    Title: MDF is a conserved splicing factor and modulates cell division and stress response in Arabidopsis.
  2. MERISTEM-DEFECTIVE regulates PIN and meristem transcription factor gene expression, and establishes the correct auxin distribution, meristem pattern and function.
    Title: MERISTEM-DEFECTIVE, an RS domain protein, is required for the correct meristem patterning and function in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001343464.1
NM_121684.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cotyledon vascular tissue pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within flower development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leaf development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leaf vascular tissue pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within meristem structural organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phloem or xylem histogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within post-embryonic root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within shoot system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
SART-1 family
NP_001318573.1
  • DEFECTIVELY ORGANIZED TRIBUTARIES 2 (DOT2); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: in 9 processes; LOCATED IN: nucleolus, nucleus; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: SART-1 protein (InterPro:IPR005011); BEST Arabidopsis thaliana protein match is: SART-1 family (TAIR:AT3G14700.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    5515707..5522261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001343465.1 → NP_001330040.1  SART-1 family [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DHM8, Q9ASS0, Q9LFE0
    UniProtKB/TrEMBL
    A0A178UP47, A0A5S9Y5F3, A0A654G2B7
    Conserved Domains (2) summary
    TIGR01622
    Location:38 → 148
    SF-CC1; splicing factor, CC1-like family
    pfam03343
    Location:171 → 727
    SART-1; SART-1 family

  2. NM_001343464.1 → NP_001318573.1  SART-1 family [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DHM8, Q9ASS0, Q9LFE0
    UniProtKB/TrEMBL
    A0A178UP47, A0A5S9Y5F3, A0A654G2B7
    Conserved Domains (2) summary
    TIGR01622
    Location:38 → 148
    SF-CC1; splicing factor, CC1-like family
    pfam03343
    Location:171 → 727
    SART-1; SART-1 family

  3. NM_121684.4 → NP_197180.1  SART-1 family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197180.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DHM8, Q9ASS0, Q9LFE0
    UniProtKB/TrEMBL
    A0A178UP47, A0A5S9Y5F3, A0A654G2B7
    Conserved Domains (2) summary
    TIGR01622
    Location:38 → 148
    SF-CC1; splicing factor, CC1-like family
    pfam03343
    Location:171 → 727
    SART-1; SART-1 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LFE0.1

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