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EXO70A1 exocyst subunit exo70 family protein A1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831809, updated on 18-Sep-2024

Summary

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Official Symbol
EXO70A1
Official Full Name
exocyst subunit exo70 family protein A1
Primary source
TAIR:AT5G03540
Locus tag
AT5G03540
See related
Araport:AT5G03540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATEXO70A1; exocyst subunit exo70 family protein A1; F12E4.330; F12E4_330
Summary
AtEXO70A1 is a member of EXO70 gene family, putative exocyst subunits, conserved in land plants. Arabidopsis thaliana contains 23 putative EXO70 genes, which can be classified into nine clusters on the phylogenetic tree
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Genomic context

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See EXO70A1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
13
Sequence:
Chromosome: 5; NC_003076.8 (889385..894205)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene C2H2-type zinc finger family protein Neighboring gene RAB GTPase homolog 8C Neighboring gene RAB GTPase homolog C2A Neighboring gene expressed in response to phosphate starvation protein Neighboring gene MATH domain/coiled-coil protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AtEXO70A1, a member of a family of putative exocyst subunits specifically expanded in land plants, is important for polar growth and plant development. Synek L, et al. Plant J, 2006 Oct. PMID 16942608, Free PMC Article
  2. Arabidopsis EXO70A1 recruits Patellin3 to the cell membrane independent of its role as an exocyst subunit. Wu C, et al. J Integr Plant Biol, 2017 Dec. PMID 28815958
  3. Transient cell-specific EXO70A1 activity in the CASP domain and Casparian strip localization. Kalmbach L, et al. Nat Plants, 2017 Apr 24. PMID 28436943
  4. Cellular pathways regulating responses to compatible and self-incompatible pollen in Brassica and Arabidopsis stigmas intersect at Exo70A1, a putative component of the exocyst complex. Samuel MA, et al. Plant Cell, 2009 Sep. PMID 19789280, Free PMC Article
  5. Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis. Zhang C, et al. Proc Natl Acad Sci U S A, 2016 Jan 5. PMID 26607451, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plasma membrane phospholipid signature recruits the plant exocyst complex via the EXO70A1 subunit.
    Title: Plasma membrane phospholipid signature recruits the plant exocyst complex via the EXO70A1 subunit.
  2. Synergy among Exocyst and SNARE Interactions Identifies a Functional Hierarchy in Secretion during Vegetative Growth.
    Title: Synergy among Exocyst and SNARE Interactions Identifies a Functional Hierarchy in Secretion during Vegetative Growth.
  3. While the apical domain recruits EXO70H4, the basal domain recruits EXO70A1, which corresponds to the lipid-binding capacities of these two paralogs. Loss of EXO70H4 results in a loss of the Ortmannian ring border and decreased apical PA accumulation, which causes the PA and PIP2 domains to merge together.
    Title: Arabidopsis Trichome Contains Two Plasma Membrane Domains with Different Lipid Compositions Which Attract Distinct EXO70 Subunits.
  4. The authors' results establish EXO70A1 as a central player in Casparian strip formation, generating a transient positional information that will be translated into a precisely localized cell wall modification.
    Title: Transient cell-specific EXO70A1 activity in the CASP domain and Casparian strip localization.
  5. Arabidopsis EXO70A1 recruits Patellin3 to the cell membrane independent of its role as an exocyst subunit
    Title: Arabidopsis EXO70A1 recruits Patellin3 to the cell membrane independent of its role as an exocyst subunit.
  6. small molecule Endosidin2 (ES2) binds to the EXO70 (exocyst component of 70 kDa) subunit of the exocyst complex, resulting in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking.
    Title: Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis.
  7. Data suggest that EXO70A1 functions in vesicle trafficking in tracheary element (TE) to regulate patterned secondary cell wall thickening.
    Title: EXO70A1-mediated vesicle trafficking is critical for tracheary element development in Arabidopsis.
  8. study implies that multiplications of EXO70 genes may allow plants to acquire cell type- and/or cargo-specific regulatory machinery for exocytosis
    Title: Expression and functional analyses of EXO70 genes in Arabidopsis implicate their roles in regulating cell type-specific exocytosis.
  9. The amount of pectinaceous mucilage and seed coat structure in sec8 and exo70A1 exocyst mutants, was characterized.
    Title: Arabidopsis exocyst subunits SEC8 and EXO70A1 and exocyst interactor ROH1 are involved in the localized deposition of seed coat pectin.
  10. Exo70A1 is a compatibility factor in the stigma. Arabidopsis lines lacking Exo70A1 in the stigma are incapable of accepting compatible pollen.
    Title: Cellular pathways regulating responses to compatible and self-incompatible pollen in Brassica and Arabidopsis stigmas intersect at Exo70A1, a putative component of the exocyst complex.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001125690.1
NM_001203287.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within auxin transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell plate assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within developmental process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lateral root morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monopolar cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mucilage biosynthetic process involved in seed coat development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within plant-type cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization involved in auxin polar transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protoxylem development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of exocyst localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of secondary cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in xylem development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in xylem vessel member cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell plate IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of exocyst IDA
Inferred from Direct Assay
more info
 PubMed 
part_of exocyst IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasmodesma HDA PubMed 
located_in pollen tube tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
exocyst subunit exo70 family protein A1
NP_001119162.1
  • exocyst subunit exo70 family protein A1 (EXO70A1); INVOLVED IN: lateral root morphogenesis, mucilage biosynthetic process involved in seed coat development, root development, vesicle docking involved in exocytosis; LOCATED IN: cytosol, nucleus, plasma membrane, membrane, exocyst; EXPRESSED IN: cultured cell, leaf; CONTAINS InterPro DOMAIN/s: Exo70 exocyst complex subunit (InterPro:IPR004140); BEST Arabidopsis thaliana protein match is: exocyst subunit exo70 family protein A2 (TAIR:AT5G52340.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_001190216.1
  • exocyst subunit exo70 family protein A1 (EXO70A1); CONTAINS InterPro DOMAIN/s: Exo70 exocyst complex subunit (InterPro:IPR004140); BEST Arabidopsis thaliana protein match is: exocyst subunit exo70 family protein A2 (TAIR:AT5G52340.1).
NP_195974.2
  • exocyst subunit exo70 family protein A1 (EXO70A1); INVOLVED IN: lateral root morphogenesis, mucilage biosynthetic process involved in seed coat development, root development, vesicle docking involved in exocytosis; LOCATED IN: cytosol, nucleus, plasma membrane, membrane, exocyst; EXPRESSED IN: cultured cell, leaf; CONTAINS InterPro DOMAIN/s: Exo70 exocyst complex subunit (InterPro:IPR004140); BEST Arabidopsis thaliana protein match is: exocyst subunit exo70 family protein A2 (TAIR:AT5G52340.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    889385..894205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120434.5 → NP_195974.2  exocyst subunit exo70 family protein A1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195974.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LZD3
    UniProtKB/TrEMBL
    A0A178UQT1, A0A5S9Y1C1, A0A654FY33
    Conserved Domains (1) summary
    pfam03081
    Location:269 → 626
    Exo70; Exo70 exocyst complex subunit

  2. NM_001125690.1 → NP_001119162.1  exocyst subunit exo70 family protein A1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001119162.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FY33, B3H609
    Conserved Domains (1) summary
    pfam03081
    Location:154 → 511
    Exo70; Exo70 exocyst complex subunit

  3. NM_001203287.1 → NP_001190216.1  exocyst subunit exo70 family protein A1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190216.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FY33, F4KGM7
    Conserved Domains (1) summary
    pfam03081
    Location:295 → 652
    Exo70; Exo70 exocyst complex subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LZD3.1

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