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DPB Transcription factor DP [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831847, updated on 18-Sep-2024

Summary

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Official Symbol
DPB
Official Full Name
Transcription factor DP
Primary source
TAIR:AT5G03415
Locus tag
AT5G03415
See related
Araport:AT5G03415
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATDPB; DPB TRANSCRIPTION FACTOR
Summary
Encodes a homolog of the animal DP protein. DP, in animals, forms a heterodimer with E2F and plays a central role in G1/S transition in the cell division cycle. DPB has been shown to interact with non phosphorylated E2Fc; when E2Fc is phosphorylated, the formation of the E2Fc/DPB heterodimer is lost.
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Genomic context

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See DPB in Genome Data Viewer
Location:
chromosome: 5
Exon count:
10
Sequence:
Chromosome: 5; NC_003076.8 (842289..845454)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Class II aaRS and biotin synthetases superfamily protein Neighboring gene 5'-AMP-activated protein kinase-like protein Neighboring gene ncRNA Neighboring gene phosphoadenosine phosphosulfate (PAPS) reductase family protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Arabidopsis cell cycle F-box protein SKP2A binds to auxin. Jurado S, et al. Plant Cell, 2010 Dec. PMID 21139066, Free PMC Article
  2. E2F sites that can interact with E2F proteins cloned from rice are required for meristematic tissue-specific expression of rice and tobacco proliferating cell nuclear antigen promoters. Kosugi S, et al. Plant J, 2002 Jan. PMID 12060226
  3. The balance between cell division and endoreplication depends on E2FC-DPB, transcription factors regulated by the ubiquitin-SCFSKP2A pathway in Arabidopsis. del Pozo JC, et al. Plant Cell, 2006 Sep. PMID 16920782, Free PMC Article
  4. Characterization of two distinct DP-related genes from Arabidopsis thaliana. Magyar Z, et al. FEBS Lett, 2000 Dec 1. PMID 11108847
  5. Interaction of the Arabidopsis E2F and DP proteins confers their concomitant nuclear translocation and transactivation. Kosugi S, et al. Plant Physiol, 2002 Mar. PMID 11891240, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The interaction of E2FC with DPB is a key factor in controlling the balance between cell proliferation and the switch to the endocycle program.
    Title: The balance between cell division and endoreplication depends on E2FC-DPB, transcription factors regulated by the ubiquitin-SCFSKP2A pathway in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001203285.1
NM_180426.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of DRM complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Transcription factor DP
NP_001190214.1
  • DPB; CONTAINS InterPro DOMAIN/s: Transcription factor E2F/dimerisation partner (TDP) (InterPro:IPR003316), Transcription factor DP, C-terminal (InterPro:IPR014889), Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Transcription factor DP (InterPro:IPR015648), Transcription factor DP, subgroup (InterPro:IPR016556); BEST Arabidopsis thaliana protein match is: Transcription factor DP (TAIR:AT5G02470.3).
NP_850757.1
  • DPB; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Transcription factor E2F/dimerisation partner (TDP) (InterPro:IPR003316), Transcription factor DP, C-terminal (InterPro:IPR014889), Transcription factor DP (InterPro:IPR015648), Transcription factor DP, subgroup (InterPro:IPR016556); BEST Arabidopsis thaliana protein match is: Transcription factor DP (TAIR:AT5G02470.3); Has 509 Blast hits to 501 proteins in 101 species: Archae - 0; Bacteria - 0; Metazoa - 249; Fungi - 7; Plants - 91; Viruses - 0; Other Eukaryotes - 162 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    842289..845454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001203285.1 → NP_001190214.1  Transcription factor DP [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190214.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UIJ9, A0A5S9Y1U8
    Conserved Domains (4) summary
    cd14458
    Location:181 → 227
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:103 → 176
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam06567
    Location:270 → 314
    Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain
    pfam08781
    Location:183 → 289
    DP; Transcription factor DP

  2. NM_180426.3 → NP_850757.1  Transcription factor DP [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850757.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LDG3, Q9FNY2, Q9LZE7
    UniProtKB/TrEMBL
    A0A178UIJ9, A0A5S9Y1U8
    Conserved Domains (4) summary
    cd14458
    Location:187 → 233
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:101 → 182
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam06567
    Location:276 → 320
    Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain
    pfam08781
    Location:189 → 295
    DP; Transcription factor DP
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FNY2.1

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