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PRK6 Leucine-rich repeat protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832192, updated on 18-Sep-2024

Summary

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Official Symbol
PRK6
Official Full Name
Leucine-rich repeat protein kinase family protein
Primary source
TAIR:AT5G20690
Locus tag
AT5G20690
See related
Araport:AT5G20690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
pollen receptor like kinase 6; T1M15.90; T1M15_90
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Genomic context

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See PRK6 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
2
Sequence:
Chromosome: 5; NC_003076.8 (7002453..7004775)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene DUF1677 family protein (DUF1677) Neighboring gene TRICHOME BIREFRINGENCE-LIKE 16 Neighboring gene senescence-associated family protein, putative (DUF581) Neighboring gene beta-galactosidase 7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis PRK6 interacts specifically with AtRopGEF8/12 and induces depolarized growth of pollen tubes when overexpressed. Yu Y, et al. Sci China Life Sci, 2018 Jan. PMID 28795376
  2. AtLURE1/PRK6-mediated signaling promotes conspecific micropylar pollen tube guidance. Liu M, et al. Plant Physiol, 2021 Jun 11. PMID 33638984, Free PMC Article
  3. The phospholipid flippase ALA3 regulates pollen tube growth and guidance in Arabidopsis. Yang Y, et al. Plant Cell, 2022 Sep 27. PMID 35861414, Free PMC Article
  4. Tip-localized receptors control pollen tube growth and LURE sensing in Arabidopsis. Takeuchi H, et al. Nature, 2016 Mar 10. PMID 26961657
  5. Structural basis for receptor recognition of pollen tube attraction peptides. Zhang X, et al. Nat Commun, 2017 Nov 6. PMID 29109411, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AtLURE1/PRK6-mediated signaling promotes conspecific micropylar pollen tube guidance.
    Title: AtLURE1/PRK6-mediated signaling promotes conspecific micropylar pollen tube guidance.
  2. Arabidopsis pollen receptor like kinase 6 (AtPRK6) is localized to the plasma membrane and expressed specifically in pollen tubes. The interactions between AtPRK6 and Arabidopsis Rop guanine nucleotide exchange factors AtRopGEF8 and AtRopGEF12 are mediated by the C-termini of AtRopGEF8/12 and by the juxtamembrane and kinase domain of AtPRK6, but are not dependent on the kinase activity.
    Title: Arabidopsis PRK6 interacts specifically with AtRopGEF8/12 and induces depolarized growth of pollen tubes when overexpressed.
  3. Structural study reveals that a C-terminal loop of the LRR domain (AtPRK6(LRR)) is responsible for recognition of AtLURE1.2, mediated by a set of residues largely conserved among PRK6 homologs from Arabidopsis lyrata and Capsella rubella, supported by in vitro mutagenesis and semi-in-vivo pollen tube growth assays.
    Title: Structural basis for receptor recognition of pollen tube attraction peptides.
  4. PRK6 acts as a key membrane receptor for external AtLURE1 attractants, and recruits the core tip-growth machinery, including ROP signalling proteins. [PRK6]
    Title: Tip-localized receptors control pollen tube growth and LURE sensing in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within pollen tube guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pollen tube guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  
located_in pollen tube tip IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Leucine-rich repeat protein kinase family protein
NP_197569.2
  • Leucine-rich repeat protein kinase family protein; FUNCTIONS IN: protein serine/threonine kinase activity, kinase activity, ATP binding; INVOLVED IN: transmembrane receptor protein tyrosine kinase signaling pathway, protein amino acid phosphorylation; LOCATED IN: endomembrane system; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT3G42880.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7002453..7004775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122076.3 → NP_197569.2  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197569.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3E991
    UniProtKB/TrEMBL
    A0A178UD78, A0A5S9Y5X8, A0A654G2Z3
    Conserved Domains (4) summary
    PLN00113
    Location:70 → 657
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:98 → 120
    LRR_RI; leucine-rich repeat [structural motif]
    pfam08263
    Location:34 → 67
    LRRNT_2; Leucine rich repeat N-terminal domain
    cl21453
    Location:390 → 656
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3E991.4

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