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LARP1a LA RNA-binding protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832242, updated on 18-Sep-2024

Summary

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Official Symbol
LARP1a
Official Full Name
LA RNA-binding protein
Primary source
TAIR:AT5G21160
Locus tag
AT5G21160
See related
Araport:AT5G21160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtLARP1a; La related protein 1a; T10F18.190; T10F18_190
Summary
Encodes a protein with sequence similarity to mRNA binding proteins from humans. LARP1a is involved in mRNA degradation in response to heat stress. Upon heat stress LARP1a interacts with XRN4 and appears to be responsible for addressing XRN4 to the polysome. LARP1/XRN4 double mutants are impaired in thermotolerance and lower levels of heat induced RNA turnover.
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Genomic context

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See LARP1a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
15
Sequence:
Chromosome: 5; NC_003076.8 (7198633..7204097, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene embryo defective 1379 Neighboring gene Argonaute family protein Neighboring gene miscRNA Neighboring gene 5'-AMP-activated protein kinase beta-2 subunit protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation. Scarpin MR, et al. Elife, 2020 Oct 15. PMID 33054972, Free PMC Article
  2. XRN4 and LARP1 are required for a heat-triggered mRNA decay pathway involved in plant acclimation and survival during thermal stress. Merret R, et al. Cell Rep, 2013 Dec 12. PMID 24332370
  3. Protein and metabolite composition of Arabidopsis stress granules. Kosmacz M, et al. New Phytol, 2019 May. PMID 30664249
  4. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings. Reichel M, et al. Plant Cell, 2016 Oct. PMID 27729395, Free PMC Article
  5. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation.
    Title: Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001203425.1
NM_001203426.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA cap binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 5'-UTR binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mRNA binding HDA PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular heat acclimation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in heat acclimation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA stabilization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of mRNA catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plastid HDA PubMed 

General protein information

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Preferred Names
LA RNA-binding protein
NP_001190354.1
  • LA RNA-binding protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), RNA-binding protein Lupus La (InterPro:IPR006630), Protein of unknown function DM15 (InterPro:IPR006607); BEST Arabidopsis thaliana protein match is: winged-helix DNA-binding transcription factor family protein (TAIR:AT4G35890.1).
NP_001190355.1
  • LA RNA-binding protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), RNA-binding protein Lupus La (InterPro:IPR006630), Protein of unknown function DM15 (InterPro:IPR006607); BEST Arabidopsis thaliana protein match is: winged-helix DNA-binding transcription factor family protein (TAIR:AT4G35890.1).
NP_568409.1
  • LA RNA-binding protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), RNA-binding protein Lupus La (InterPro:IPR006630), Protein of unknown function DM15 (InterPro:IPR006607); BEST Arabidopsis thaliana protein match is: winged-helix DNA-binding transcription factor family protein (TAIR:AT4G35890.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7198633..7204097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122123.3 → NP_568409.1  LA RNA-binding protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568409.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q56WZ6, Q940X9
    UniProtKB/TrEMBL
    A0A654G2Y7
    Conserved Domains (2) summary
    smart00684
    Location:712 → 749
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd07323
    Location:279 → 351
    LAM; LA motif RNA-binding domain

  2. NM_001203426.1 → NP_001190355.1  LA RNA-binding protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190355.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654G2Y7, F4K703
    Conserved Domains (2) summary
    smart00684
    Location:712 → 749
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd07323
    Location:279 → 351
    LAM; LA motif RNA-binding domain

  3. NM_001203425.1 → NP_001190354.1  LA RNA-binding protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190354.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654G2Y7, F4K704
    Conserved Domains (2) summary
    smart00684
    Location:712 → 749
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd07323
    Location:279 → 351
    LAM; LA motif RNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q940X9.1

Gene LinkOut

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