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TK1b Thymidine kinase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832371, updated on 18-Sep-2024

Summary

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Official Symbol
TK1b
Official Full Name
Thymidine kinase
Primary source
TAIR:AT5G23070
Locus tag
AT5G23070
See related
Araport:AT5G23070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtTK1b; MYJ24.6; MYJ24_6; thymidine kinase 1b
Summary
Encodes a thymidine kinase that salvages DNA precursors.
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Genomic context

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See TK1b in Genome Data Viewer
Location:
chromosome: 5
Exon count:
1
Sequence:
Chromosome: 5; NC_003076.8 (7741792..7742978)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene SWAP (Suppressor-of-White-APricot)/surp domain-containing protein Neighboring gene nuclear factor Y, subunit B13 Neighboring gene MIZU-KUSSEI-like protein (Protein of unknown function, DUF617)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of pyrimidine salvage pathway in the maintenance of organellar and nuclear genome integrity. Pedroza-García JA, et al. Plant J, 2019 Feb. PMID 30317699
  2. Thymidine kinases share a conserved function for nucleotide salvage and play an essential role in Arabidopsis thaliana growth and development. Xu J, et al. New Phytol, 2015 Dec. PMID 26139575
  3. Efficient Replication of the Plastid Genome Requires an Organellar Thymidine Kinase. Le Ret M, et al. Plant Physiol, 2018 Dec. PMID 30305373, Free PMC Article
  4. Two thymidine kinases and one multisubstrate deoxyribonucleoside kinase salvage DNA precursors in Arabidopsis thaliana. Clausen AR, et al. FEBS J, 2012 Oct. PMID 22897443
  5. Thymidine kinase 1 regulatory fine-tuning through tetramer formation. Mutahir Z, et al. FEBS J, 2013 Mar. PMID 23351158

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TK1B is required for efficient chloroplast DNA replication and chloroplast biogenesis.
    Title: Efficient Replication of the Plastid Genome Requires an Organellar Thymidine Kinase.
  2. Findings clarify the specialized function of two TKs in A. thaliana and establish that the [nucleotide] salvage pathway mediated by the kinases is essential for plant growth and development. [AtTK2]
    Title: Thymidine kinases share a conserved function for nucleotide salvage and play an essential role in Arabidopsis thaliana growth and development.
  3. Data show that thymidine kinase was encoded by AtTK1a (AT3G07800) and (AT5G23070), and deoxyadenosine, deoxyguanosine and deoxycytidine kinase activities were encoded by a single AtdNK (AT1G72040) gene.
    Title: Two thymidine kinases and one multisubstrate deoxyribonucleoside kinase salvage DNA precursors in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_122213.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thymidine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within seedling development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Thymidine kinase
NP_568426.1
  • Thymidine kinase; FUNCTIONS IN: thymidine kinase activity, ATP binding; INVOLVED IN: pyrimidine deoxyribonucleoside interconversion, anaerobic respiration; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thymidine kinase (InterPro:IPR001267), Thymidine kinase, conserved site (InterPro:IPR020633); BEST Arabidopsis thaliana protein match is: Thymidine kinase (TAIR:AT3G07800.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7741792..7742978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122213.4 → NP_568426.1  Thymidine kinase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568426.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4KBF5, Q9FN47
    UniProtKB/TrEMBL
    A0A178UCI4, A0A5S9Y705, A0A654G3I6, A0A7G2FAI5
    Conserved Domains (1) summary
    cl23762
    Location:77 → 259
    TK; Thymidine kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4KBF5.1

Gene LinkOut

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