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PYRD pyrimidine d [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832394, updated on 18-Sep-2024

Summary

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Official Symbol
PYRD
Official Full Name
pyrimidine d
Primary source
TAIR:AT5G23300
Locus tag
AT5G23300
See related
Araport:AT5G23300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
DIHYDROOROTATE DEHYDROGENASE; MKD15.16; MKD15_16; pyrimidine d
Summary
dihydroorotate dehydrogenase, catalyses fourth step of pyrimidine biosynthesis
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Genomic context

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See PYRD in Genome Data Viewer
Location:
chromosome: 5
Exon count:
10
Sequence:
Chromosome: 5; NC_003076.8 (7847587..7850404, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene sugar transporter 11 Neighboring gene TCP family transcription factor Neighboring gene prefoldin 5 Neighboring gene Fe superoxide dismutase 3 Neighboring gene S-isoprenylcysteine O-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plant dihydroorotate dehydrogenase differs significantly in substrate specificity and inhibition from the animal enzymes. Ullrich A, et al. FEBS Lett, 2002 Oct 9. PMID 12372626
  2. Complementation of Saccharomyces cerevisiae auxotrophic mutants by Arabidopsis thaliana cDNAs. Minet M, et al. Plant J, 1992 May. PMID 1303803
  3. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
  4. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article
  5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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NM_122236.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables dihydroorotate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydroorotate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydroorotate dehydrogenase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pyrimidine ribonucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within pyrimidine ribonucleotide biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in plastid HDA PubMed 

General protein information

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Preferred Names
pyrimidine d
NP_568428.1
  • pyrimidine d (PYRD); FUNCTIONS IN: dihydroorotate dehydrogenase activity; INVOLVED IN: 'de novo' pyrimidine base biosynthetic process, pyrimidine ribonucleotide biosynthetic process; LOCATED IN: mitochondrion; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Dihydroorotate dehydrogenase, conserved site (InterPro:IPR001295), Aldolase-type TIM barrel (InterPro:IPR013785), Dihydroorotate dehydrogenase, class 2 (InterPro:IPR005719), Dihydroorotate dehydrogenase, class 1/ 2 (InterPro:IPR012135); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7847587..7850404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122236.3 → NP_568428.1  pyrimidine d [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568428.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32746, Q0WRX8, Q9FMX1
    UniProtKB/TrEMBL
    A0A178URD4, A0A5S9Y7F4, A0A7G2FCH0
    Conserved Domains (1) summary
    PLN02826
    Location:51 → 460
    PLN02826; dihydroorotate dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32746.2

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