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SWEET12 bidirectional sugar transporter SWEET12-like protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832431, updated on 18-Sep-2024

Summary

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Official Symbol
SWEET12
Official Full Name
bidirectional sugar transporter SWEET12-like protein
Primary source
TAIR:AT5G23660
Locus tag
AT5G23660
See related
Araport:AT5G23660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtSWEET12; homolog of Medicago truncatula MTN3; MQM1.8; MQM1_8; MTN3
Summary
Encodes a member of the SWEET sucrose efflux transporter family proteins.
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Genomic context

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See SWEET12 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Sequence:
Chromosome: 5; NC_003076.8 (7971647..7973995, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene phosphate deficiency response 2 Neighboring gene Homeodomain-like transcriptional regulator Neighboring gene ncRNA Neighboring gene tRNA-Gln

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two evolutionarily duplicated domains individually and post-transcriptionally control SWEET expression for phloem transport. Zhang C, et al. New Phytol, 2021 Nov. PMID 34431115
  2. Disruption of the Sugar Transporters AtSWEET11 and AtSWEET12 Affects Vascular Development and Freezing Tolerance in Arabidopsis. Le Hir R, et al. Mol Plant, 2015 Nov 2. PMID 26358680
  3. A cascade of sequentially expressed sucrose transporters in the seed coat and endosperm provides nutrition for the Arabidopsis embryo. Chen LQ, et al. Plant Cell, 2015 Mar. PMID 25794936, Free PMC Article
  4. Water Deficit Enhances C Export to the Roots in Arabidopsis thaliana Plants with Contribution of Sucrose Transporters in Both Shoot and Roots. Durand M, et al. Plant Physiol, 2016 Mar. PMID 26802041, Free PMC Article
  5. Sucrose efflux mediated by SWEET proteins as a key step for phloem transport. Chen LQ, et al. Science, 2012 Jan 13. PMID 22157085

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two evolutionarily duplicated domains individually and post-transcriptionally control SWEET expression for phloem transport.
    Title: Two evolutionarily duplicated domains individually and post-transcriptionally control SWEET expression for phloem transport.
  2. Data indicate that the transcript levels of sucrose transporters AtSUC2, AtSWEET11, AtSWEET12 and AtSWEET15 were significantly higher in stressed roots.
    Title: Water Deficit Enhances C Export to the Roots in Arabidopsis thaliana Plants with Contribution of Sucrose Transporters in Both Shoot and Roots.
  3. in addition to their contribution to phloem loading in source leaves, the AtSWEET11 and AtSWEET12 proteins act as sugar exporters that deliver carbon-containing skeletons to developing xylem cells in order to support secondary cell wall formation
    Title: Disruption of the Sugar Transporters AtSWEET11 and AtSWEET12 Affects Vascular Development and Freezing Tolerance in Arabidopsis.
  4. SWEET11, 12, and 15 exhibit specific spatiotemporal expression patterns in developing seeds.
    Title: A cascade of sequentially expressed sucrose transporters in the seed coat and endosperm provides nutrition for the Arabidopsis embryo.
  5. identified subfamily of SWEET sucrose efflux transporters; AtSWEET11 and 12 localize to plasma membrane of phloem; mutant plants carrying insertions in AtSWEET11 and 12 are defective in phloem loading evealing a 2 step mechanism of SWEET-mediated export
    Title: Sucrose efflux mediated by SWEET proteins as a key step for phloem transport.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_122271.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sucrose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sugar transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in seed maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sucrose transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sucrose transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
bidirectional sugar transporter SWEET12-like protein
NP_197755.1
  • homolog of Medicago truncatula MTN3 (MTN3); INVOLVED IN: biological_process unknown; LOCATED IN: endomembrane system, integral to membrane, membrane; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: MtN3/saliva-related transmembrane protein, conserved region (InterPro:IPR018169), RAG1-activating protein 1 homologue (InterPro:IPR018179), RAG1-activating protein-1-related (InterPro:IPR004316); BEST Arabidopsis thaliana protein match is: Nodulin MtN3 family protein (TAIR:AT3G48740.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7971647..7973995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122271.3 → NP_197755.1  bidirectional sugar transporter SWEET12-like protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197755.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82587
    UniProtKB/TrEMBL
    A0A178U8D4
    Conserved Domains (1) summary
    pfam03083
    Location:133 → 219
    MtN3_slv; Sugar efflux transporter for intercellular exchange
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O82587.1

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