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FLOT1 SPFH/Band 7/PHB domain-containing membrane-associated protein family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832596, updated on 18-Sep-2024

Summary

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Official Symbol
FLOT1
Official Full Name
SPFH/Band 7/PHB domain-containing membrane-associated protein family
Primary source
TAIR:AT5G25250
Locus tag
AT5G25250
See related
Araport:AT5G25250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F21J6.108; F21J6_108; flotillin 1
Summary
Encodes a protein that is involved in a membrane microdomain-dependent, but clathrin-independent, endocytic pathway required for optimal seedling development.
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Genomic context

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See FLOT1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
2
Sequence:
Chromosome: 5; NC_003076.8 (8749680..8751636)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene stress induced protein Neighboring gene ncRNA Neighboring gene SPFH/Band 7/PHB domain-containing membrane-associated protein family Neighboring gene Hyp O-arabinosyltransferase-like protein Neighboring gene Ubiquitin-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A membrane microdomain-associated protein, Arabidopsis Flot1, is involved in a clathrin-independent endocytic pathway and is required for seedling development. Li R, et al. Plant Cell, 2012 May. PMID 22589463, Free PMC Article
  2. Cell wall contributes to the stability of plasma membrane nanodomain organization of Arabidopsis thaliana FLOTILLIN2 and HYPERSENSITIVE INDUCED REACTION1 proteins. Daněk M, et al. Plant J, 2020 Feb. PMID 31610051
  3. The AP2/ERF transcription factor AtERF73/HRE1 modulates ethylene responses during hypoxia in Arabidopsis. Yang CY, et al. Plant Physiol, 2011 May. PMID 21398256, Free PMC Article
  4. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article
  5. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_122434.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within endocytosis IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within membrane invagination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasmodesma HDA PubMed 
located_in plastid HDA PubMed 

General protein information

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Preferred Names
SPFH/Band 7/PHB domain-containing membrane-associated protein family
NP_197907.1
  • SPFH/Band 7/PHB domain-containing membrane-associated protein family; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: plasma membrane, vacuole; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: Band 7 protein (InterPro:IPR001107); BEST Arabidopsis thaliana protein match is: SPFH/Band 7/PHB domain-containing membrane-associated protein family (TAIR:AT5G25260.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    8749680..8751636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122434.3 → NP_197907.1  SPFH/Band 7/PHB domain-containing membrane-associated protein family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197907.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q501E6
    UniProtKB/TrEMBL
    A0A178UMD2, A0A5S9Y871
    Conserved Domains (2) summary
    cd03399
    Location:28 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl21478
    Location:258 → 331
    ATP-synt_B; ATP synthase B/B' CF(0)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q501E6.1

Gene LinkOut

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