NADP-ME3 NADP-malic enzyme 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: NADP-ME3
Official Full Name: NADP-malic enzyme 3
Primary source: TAIR:AT5G25880
Locus tag: AT5G25880
See related: Araport:AT5G25880
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: Arabidopsis thaliana NADP-malic enzyme 3; ATNADP-ME3; NADP-malic enzyme 3; T1N24.25; T1N24_25
Summary: The malic enzyme (EC 1.1.1.40) encoded by the ATNADP-ME3 is presumably cytosolic and restricted in its expression by both developmental and cell-specific signals.
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Genomic context

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See NADP-ME3 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 19

Sequence:: Chromosome: 5; NC_003076.8 (9024334..9028395)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

although the active sites of NADP-ME2 and NADP-ME3 are highly conserved, both isoenzymes acquire different allosteric sites, leading to the creation of proteins with unique regulatory mechanisms
Title: Identification of domains involved in the allosteric regulation of cytosolic Arabidopsis thaliana NADP-malic enzymes.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001343951.1

Supported by ESTs:

NM_001343952.1

Supported by ESTs:

NM_122489.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables malate dehydrogenase (decarboxylating) (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables oxaloacetate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within malate metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: NADP-malic enzyme 3

NP_197960.1

NADP-malic enzyme 3 (NADP-ME3); FUNCTIONS IN: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity, oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor, malic enzyme activity; INVOLVED IN: N-terminal protein myristoylation, malate metabolic process, protein homooligomerization; LOCATED IN: cytosol; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Malic enzyme, NAD-binding (InterPro:IPR012302), Malic oxidoreductase (InterPro:IPR001891), Malic enzyme, conserved site (InterPro:IPR015884), Malic enzyme, N-terminal (InterPro:IPR012301), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NADP-malic enzyme 2 (TAIR:AT5G11670.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

9024334..9028395

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_122489.3 → NP_197960.1 NADP-malic enzyme 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197960.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XGZ0

UniProtKB/TrEMBL

A0A178UAR6, A0A5S9Y7H5

Conserved Domains (1) summary

PLN03129
Location:20 → 588

PLN03129; NADP-dependent malic enzyme; Provisional
NM_001343952.1 → NP_001331265.1 NADP-malic enzyme 3 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BDF1

Conserved Domains (1) summary

PLN03129
Location:20 → 461

PLN03129; NADP-dependent malic enzyme; Provisional
NM_001343951.1 → NP_001331266.1 NADP-malic enzyme 3 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BDG6, A0A5S9Y7H5

Conserved Domains (1) summary

PLN03129
Location:20 → 560

PLN03129; NADP-dependent malic enzyme; Provisional