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CLC-D chloride channel D [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832693, updated on 18-Sep-2024

Summary

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Official Symbol
CLC-D
Official Full Name
chloride channel D
Primary source
TAIR:AT5G26240
Locus tag
AT5G26240
See related
Araport:AT5G26240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATCLC-D; AtCLCd; chloride channel D; CHLORIDE CHANNEL D; CLCd; T19G15.90; T19G15_90
Summary
member of Anion channel protein family
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Genomic context

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See CLC-D in Genome Data Viewer
Location:
chromosome: 5
Exon count:
22
Sequence:
Chromosome: 5; NC_003076.8 (9189425..9194758)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Major facilitator superfamily protein Neighboring gene TRAF-like family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Function of the anion transporter AtCLC-d in the trans-Golgi network. von der Fecht-Bartenbach J, et al. Plant J, 2007 May. PMID 17376158, Free PMC Article
  2. The chloride channel family gene CLCd negatively regulates pathogen-associated molecular pattern (PAMP)-triggered immunity in Arabidopsis. Guo W, et al. J Exp Bot, 2014 Mar. PMID 24449384, Free PMC Article
  3. A family of putative chloride channels from Arabidopsis and functional complementation of a yeast strain with a CLC gene disruption. Hechenberger M, et al. J Biol Chem, 1996 Dec 27. PMID 8969232
  4. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AtCLCd negatively regulates pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI).
    Title: The chloride channel family gene CLCd negatively regulates pathogen-associated molecular pattern (PAMP)-triggered immunity in Arabidopsis.
  2. The functional role of CLC-D in the trans-Golgi network is reported.
    Title: Function of the anion transporter AtCLC-d in the trans-Golgi network.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001343969.1
NM_122525.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables monoatomic anion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated chloride channel activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in intracellular monoatomic anion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to metal ion IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within unidimensional cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular anatomical structure IC
Inferred by Curator
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chloride channel D
NP_197996.1
  • chloride channel D (CLC-D); CONTAINS InterPro DOMAIN/s: Chloride channel, core (InterPro:IPR014743), Chloride channel, voltage gated (InterPro:IPR001807), Chloride channel ClC-plant (InterPro:IPR002251), Cystathionine beta-synthase, core (InterPro:IPR000644); BEST Arabidopsis thaliana protein match is: chloride channel C (TAIR:AT5G49890.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    9189425..9194758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122525.3 → NP_197996.1  chloride channel D [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197996.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81491, P92943
    UniProtKB/TrEMBL
    A0A178U6J2, A0A5S9Y7C2, A0A654G4J8
    Conserved Domains (2) summary
    cd03685
    Location:45 → 574
    ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...
    cd04591
    Location:593 → 751
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

  2. NM_001343969.1 → NP_001330038.1  chloride channel D [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178U8S4, A0A1P8B9J9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P92943.2

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