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MIRO1 MIRO-related GTP-ase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832814, updated on 18-Sep-2024

Summary

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Official Symbol
MIRO1
Official Full Name
MIRO-related GTP-ase 1
Primary source
TAIR:AT5G27540
Locus tag
AT5G27540
See related
Araport:AT5G27540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
emb2473; embryo defective 2473; F21A20.250; F21A20_250; MIRO-related GTP-ase 1
Summary
Encodes a protein with similarity to GTPases that is localized to the mitochondrion. Involved in embryogenesis, pollen tube growth and required for mitochondrial development.
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Genomic context

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See MIRO1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
15
Sequence:
Chromosome: 5; NC_003076.8 (9722416..9727454)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene peroxisomal adenine nucleotide carrier 2 Neighboring gene Pectin lyase-like superfamily protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene DUF1995 domain protein, putative (DUF1995) Neighboring gene cell division cycle 20.2, cofactor of APC complex-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MIRO1 influences the morphology and intracellular distribution of mitochondria during embryonic cell division in Arabidopsis. Yamaoka S, et al. Plant Cell Rep, 2011 Feb. PMID 20931334
  2. Arabidopsis thaliana MIRO1 and MIRO2 GTPases are unequally redundant in pollen tube growth and fusion of polar nuclei during female gametogenesis. Sørmo CG, et al. PLoS One, 2011 Apr 11. PMID 21494602, Free PMC Article
  3. EMB2473/MIRO1, an Arabidopsis Miro GTPase, is required for embryogenesis and influences mitochondrial morphology in pollen. Yamaoka S, et al. Plant Cell, 2008 Mar. PMID 18344283, Free PMC Article
  4. The hydrophobic proteome of mitochondrial membranes from Arabidopsis cell suspensions. Brugière S, et al. Phytochemistry, 2004 Jun. PMID 15276431
  5. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MIRO1 and MIRO2 are unequally redundant and that a proportion of the miro1(+/-)/miro2(-/-) plants haploid gametes displays the complete null phenotype of MIRO GTPase function at key developmental stages.
    Title: Arabidopsis thaliana MIRO1 and MIRO2 GTPases are unequally redundant in pollen tube growth and fusion of polar nuclei during female gametogenesis.
  2. proper mitochondrial morphology and intracellular distribution are maintained by MIRO1 and are vital for embryonic cell division
    Title: MIRO1 influences the morphology and intracellular distribution of mitochondria during embryonic cell division in Arabidopsis.
  3. Findings suggest that mitochondrial morphology is influenced by MIRO1 and plays a vital role during embryogenesis and pollen tube growth.
    Title: EMB2473/MIRO1, an Arabidopsis Miro GTPase, is required for embryogenesis and influences mitochondrial morphology in pollen.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001036876.2
NM_122636.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo development ending in seed dormancy NAS
Non-traceable Author Statement
more info
  
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen tube growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in plastid HDA PubMed 

General protein information

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Preferred Names
MIRO-related GTP-ase 1
NP_001031953.1
  • MIRO-related GTP-ase 1 (MIRO1); FUNCTIONS IN: GTP binding; INVOLVED IN: pollen tube growth, mitochondrion organization, embryo development, embryo development ending in seed dormancy; LOCATED IN: mitochondrion; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF hand associated, type-1 (InterPro:IPR013566), Mitochondrial Rho-like (InterPro:IPR013684), EF hand associated, type-2 (InterPro:IPR013567), Ras GTPase (InterPro:IPR001806), Small GTP-binding protein (InterPro:IPR005225), Small GTPase (InterPro:IPR020851), Mitochondrial Rho GTPase (InterPro:IPR021181), MIRO (InterPro:IPR020860); BEST Arabidopsis thaliana protein match is: MIRO-related GTP-ase 2 (TAIR:AT3G63150.1); Has 8016 Blast hits to 7980 proteins in 467 species: Archae - 6; Bacteria - 176; Metazoa - 4167; Fungi - 1485; Plants - 887; Viruses - 0; Other Eukaryotes - 1295 (source: NCBI BLink).
NP_198106.1
  • MIRO-related GTP-ase 1 (MIRO1); FUNCTIONS IN: GTP binding; INVOLVED IN: pollen tube growth, mitochondrion organization, embryo development, embryo development ending in seed dormancy; LOCATED IN: mitochondrion; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF hand associated, type-1 (InterPro:IPR013566), Mitochondrial Rho-like (InterPro:IPR013684), EF hand associated, type-2 (InterPro:IPR013567), Ras GTPase (InterPro:IPR001806), Small GTP-binding protein (InterPro:IPR005225), Small GTPase (InterPro:IPR020851), Mitochondrial Rho GTPase (InterPro:IPR021181), MIRO (InterPro:IPR020860); BEST Arabidopsis thaliana protein match is: MIRO-related GTP-ase 2 (TAIR:AT3G63150.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    9722416..9727454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001036876.2 → NP_001031953.1  MIRO-related GTP-ase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031953.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RXF8
    UniProtKB/TrEMBL
    A0A178UBE1, A0A5S9Y8T3
    Conserved Domains (4) summary
    cd01892
    Location:426 → 608
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:16 → 183
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:356 → 410
    EF_assoc_1; EF hand associated
    pfam08356
    Location:233 → 317
    EF_assoc_2; EF hand associated

  2. NM_122636.4 → NP_198106.1  MIRO-related GTP-ase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_198106.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RXF8
    UniProtKB/TrEMBL
    A0A178UBE1, A0A5S9Y8T3
    Conserved Domains (4) summary
    cd01892
    Location:426 → 608
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:16 → 183
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:356 → 410
    EF_assoc_1; EF hand associated
    pfam08356
    Location:233 → 317
    EF_assoc_2; EF hand associated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8RXF8.1

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