Klb klotho beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klbprovided by MGI
Official Full Name: klotho betaprovided by MGI
Primary source: MGI:MGI:1932466
See related: Ensembl:ENSMUSG00000029195 AllianceGenome:MGI:1932466
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: betaKlotho
Summary: Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in membrane. Is expressed in several structures, including extraembryonic component; gut; liver; lung; and thymus. Orthologous to human KLB (klotho beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 12.8), placenta adult (RPKM 10.5) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.1; 5 33.64 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (65505754..65544300)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (65348411..65386957)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via beta-Klotho and perilipin 2.
Title: Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2.
Feto-maternal cholesterol transport regulated by beta-Klotho-FGF15 axis is essential for fetal growth.
Title: Feto-maternal cholesterol transport regulated by β-Klotho-FGF15 axis is essential for fetal growth.
Intestinal epithelial beta Klotho is a critical protective factor in alcohol-induced intestinal barrier dysfunction and liver injury.
Title: Intestinal epithelial β Klotho is a critical protective factor in alcohol-induced intestinal barrier dysfunction and liver injury.
Glucagon receptor signaling regulates weight loss via central KLB receptor complexes.
Title: Glucagon receptor signaling regulates weight loss via central KLB receptor complexes.
Levels of beta-klotho determine the thermogenic responsiveness of adipose tissues: involvement of the autocrine action of FGF21.
Title: Levels of β-klotho determine the thermogenic responsiveness of adipose tissues: involvement of the autocrine action of FGF21.
Study demonstrated, for the first time, that betaKlotho was strongly expressed in cells infiltrating the lesional dermis of psoriatic patients compared with control or atopic dermatitis patients and in cells infiltrating the skin of imiquimod-treated mice than in untreated mice.
Title: Macrophages express βKlotho in skin lesions of psoriatic patients and the skin of imiquimod-treated mice.
Klb(-/-) mice present permanent growth restriction independent of adiposity and energy balance. Klb(-/-) mice also exhibit few changes in carbohydrate metabolism, combining normal gluco-tolerance, insulin sensitivity, and fasting response with increased gluconeogenic capacity and decreased glycogen mobilization. Livers of Klb(-/-) mice have pathologic features, including a proinflammatory status and initiation of fibrosis
Title: β-Klotho deficiency shifts the gut-liver bile acid axis and induces hepatic alterations in mice.
Downregulation of beta-klotho expression is not the major mechanism of impaired FGF21 signaling in white adipose tissue.
Title: FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue.
liver FGF21-betaKlotho pathway sufficient and necessary to repress mTOR/S6K activity
Title: Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice.
The study supports a pro-adipogenic role for betaKlotho in skeletal muscle fibro/adipogenesis and calls for further research on involvement of the FGF-FGFR-betaKlotho axis in the fibro/adipogenic infiltration associated with functional deterioration of skeletal muscle in aging and muscular dystrophy.
Title: Expression profile and overexpression outcome indicate a role for βKlotho in skeletal muscle fibro/adipogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Gene trapped (1)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibroblast growth factor binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-klotho

Names: BKL; klotho beta-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.