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MRN1 marneral synthase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834267, updated on 18-Sep-2024

Summary

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Official Symbol
MRN1
Official Full Name
marneral synthase
Primary source
TAIR:AT5G42600
Locus tag
AT5G42600
See related
Araport:AT5G42600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
marneral synthase; marneral synthase 1; MFO20.1; MFO20_1
Summary
Encodes an oxidosqualene synthase that produces the monocyclic triterpene marneral. Crucial for growth and development.
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Genomic context

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See MRN1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
14
Sequence:
Chromosome: 5; NC_003076.8 (17053453..17058245)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene calcium uniporter (DUF607) Neighboring gene metalloendopeptidase / zinc ion binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of marneral synthase, which is critical for growth and development in Arabidopsis. Go YS, et al. Plant J, 2012 Dec. PMID 22882494
  2. An Arabidopsis oxidosqualene cyclase catalyzes iridal skeleton formation by Grob fragmentation. Xiong Q, et al. Angew Chem Int Ed Engl, 2006 Feb 13. PMID 16425307
  3. Formation of plant metabolic gene clusters within dynamic chromosomal regions. Field B, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21876149, Free PMC Article
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. triterpenoid pathway via marneral synthase is important for the growth and development of Arabidopsis
    Title: Identification of marneral synthase, which is critical for growth and development in Arabidopsis.
  2. Data show taht MRN1 (At5g42600) is flanked by two coexpressed cytochrome P450 genes that belong to different P450 families.
    Title: Formation of plant metabolic gene clusters within dynamic chromosomal regions.
  3. Results describe marneral synthase, an oxidosqualene cyclase that catalyzes iridal skeleton formation by Grob fragmentation.
    Title: An Arabidopsis oxidosqualene cyclase catalyzes iridal skeleton formation by Grob fragmentation.
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Pathways from PubChem

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General gene information

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NM_123624.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables marneral synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within triterpenoid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
marneral synthase
NP_199074.1
  • marneral synthase (MRN1); CONTAINS InterPro DOMAIN/s: Terpene synthase, conserved site (InterPro:IPR002365), Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (InterPro:IPR008930), Squalene cyclase (InterPro:IPR018333), Prenyltransferase/squalene oxidase (InterPro:IPR001330); BEST Arabidopsis thaliana protein match is: Terpenoid cyclases family protein (TAIR:AT1G78500.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    17053453..17058245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_123624.4 → NP_199074.1  marneral synthase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199074.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FJV8
    UniProtKB/TrEMBL
    A0A5S9YBF5
    Conserved Domains (1) summary
    PLN03012
    Location:1 → 752
    PLN03012; Camelliol C synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FJV8.1

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