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NPR3 NPR1-like protein 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834545, updated on 18-Sep-2024

Summary

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Official Symbol
NPR3
Official Full Name
NPR1-like protein 3
Primary source
TAIR:AT5G45110
Locus tag
AT5G45110
See related
Araport:AT5G45110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATNPR3; K17O22.11; K17O22_11; NPR1-like protein 3
Summary
Encodes NPR3, a paralog of NPR1. Involved in negative regulation of defense responses against bacterial and oomycete pathogens. npr3 mutants has elevated level of PR1 expression. Interacts with TGA2, TGA3, TGA5 and TGA6 in yeast two hybrid assays. NPR3 and NPR4 are receptors for the immune signal salicylic acid.
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Genomic context

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See NPR3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
4
Sequence:
Chromosome: 5; NC_003076.8 (18228768..18231588)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene SBP (S-ribonuclease binding protein) family protein Neighboring gene miscRNA Neighboring gene mitochondrial transcription termination factor-related / mTERF-like protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Salicylic Acid Regulates Pollen Tip Growth through an NPR3/NPR4-Independent Pathway. Rong D, et al. Mol Plant, 2016 Nov 7. PMID 27575693, Free PMC Article
  2. Structural basis of salicylic acid perception by Arabidopsis NPR proteins. Wang W, et al. Nature, 2020 Oct. PMID 32788727, Free PMC Article
  3. Opposite Roles of Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Transcriptional Regulation of Plant Immunity. Ding Y, et al. Cell, 2018 May 31. PMID 29656896
  4. The salicylic acid receptor NPR3 is a negative regulator of the transcriptional defense response during early flower development in Arabidopsis. Shi Z, et al. Mol Plant, 2013 May. PMID 22986789
  5. NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants. Fu ZQ, et al. Nature, 2012 May 16. PMID 22699612, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. both NPR1 and NPR3/NPR4 are bona fide salicylic acid receptors, but play opposite roles in transcriptional regulation of salicylic acid-induced defense gene expression
    Title: Opposite Roles of Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Transcriptional Regulation of Plant Immunity.
  2. Salicylic Acid Regulates Pollen Tip Growth through an NPR3/NPR4-Independent Pathway
    Title: Salicylic Acid Regulates Pollen Tip Growth through an NPR3/NPR4-Independent Pathway.
  3. NPR3 expression was strongest in the petals and sepals of developing flowers and declined after flower opening.
    Title: The salicylic acid receptor NPR3 is a negative regulator of the transcriptional defense response during early flower development in Arabidopsis.
  4. the NPR1 paralogues NPR3 and NPR4 are SA receptors that bind salicylic acid with different affinities
    Title: NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants.
  5. NPR3 and NPR4 negatively regulate PR gene expression and pathogen resistance through their association with TGA2 and its paralogs.[NPR3]
    Title: Negative regulation of defense responses in Arabidopsis by two NPR1 paralogs.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001344586.1
NM_123879.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables salicylic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables salicylic acid binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plant-type hypersensitive response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of jasmonic acid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of salicylic acid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of systemic acquired resistance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to salicylic acid IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within systemic acquired resistance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in systemic acquired resistance, salicylic acid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
NPR1-like protein 3
NP_199324.2
  • NPR1-like protein 3 (NPR3); INVOLVED IN: defense response to fungus, incompatible interaction, defense response to bacterium, incompatible interaction; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: BTB/POZ (InterPro:IPR013069), NPR1/NIM1 like, C-terminal (InterPro:IPR021094), BTB/POZ fold (InterPro:IPR011333), Ankyrin repeat-containing domain (InterPro:IPR020683), BTB/POZ-like (InterPro:IPR000210), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: NPR1-like protein 4 (TAIR:AT4G19660.1); Has 2270 Blast hits to 1933 proteins in 191 species: Archae - 0; Bacteria - 121; Metazoa - 545; Fungi - 58; Plants - 638; Viruses - 9; Other Eukaryotes - 899 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    18228768..18231588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_123879.3 → NP_199324.2  NPR1-like protein 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199324.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8L746, Q9FHE3
    UniProtKB/TrEMBL
    A0A178UGU4, A0A5S9YBC2, A0A7G2FKH6
    Conserved Domains (5) summary
    sd00045
    Location:295 → 322
    ANK; ANK repeat [structural motif]
    pfam11900
    Location:220 → 267
    DUF3420; Domain of unknown function (DUF3420)
    cd18310
    Location:42 → 185
    BTB_POZ_NPR_plant; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins
    pfam12313
    Location:366 → 561
    NPR1_like_C; NPR1/NIM1 like defense protein C terminal
    pfam12796
    Location:269 → 350
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001344586.1 → NP_001330386.1  NPR1-like protein 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BAP1, A0A7G2FKH6
    Conserved Domains (5) summary
    sd00045
    Location:295 → 322
    ANK; ANK repeat [structural motif]
    pfam11900
    Location:220 → 267
    DUF3420; Domain of unknown function (DUF3420)
    cd18310
    Location:42 → 185
    BTB_POZ_NPR_plant; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins
    pfam12313
    Location:366 → 495
    NPR1_like_C; NPR1/NIM1 like defense protein C terminal
    pfam12796
    Location:269 → 350
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8L746.1

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