Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: Disease resistance protein (TIR-NBS-LRR class) family
Primary source: TAIR:AT5G45210
Locus tag: AT5G45210
See related: Araport:AT5G45210
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: K18C1.9; K18C1_9
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 3

Sequence:: Chromosome: 5; NC_003076.8 (18295437..18298642)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ADP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Disease resistance protein (TIR-NBS-LRR class) family

NP_199334.1

Disease resistance protein (TIR-NBS-LRR class) family; FUNCTIONS IN: transmembrane receptor activity, ATP binding; INVOLVED IN: signal transduction, apoptosis, defense response, innate immune response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: root; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT3G51560.1); Has 10308 Blast hits to 9808 proteins in 326 species: Archae - 8; Bacteria - 189; Metazoa - 13; Fungi - 1; Plants - 9989; Viruses - 0; Other Eukaryotes - 108 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

18295437..18298642

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001344599.1 → NP_001332331.1 Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BGN8
NM_001344598.1 → NP_001332328.1 Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178U9C1, A0A1P8BGK7
NM_001344600.1 → NP_001332330.1 Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BGN2, A0A654G864
NM_001344601.1 → NP_001332329.1 Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BGN6, A0A654G864
NM_123889.2 → NP_199334.1 Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199334.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654G864, Q9FKE4

Conserved Domains (6) summary

cd00009
Location:196 → 304

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

sd00033
Location:530 → 558

LRR_RI; leucine-rich repeat [structural motif]

pfam01582
Location:9 → 168

TIR; TIR domain

pfam07725
Location:580 → 599

LRR_3; Leucine Rich Repeat

pfam12799
Location:625 → 658

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:579 → 658

LRR_8; Leucine rich repeat