APG7 ThiF family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: APG7
Official Full Name: ThiF family protein
Primary source: TAIR:AT5G45900
Locus tag: AT5G45900
See related: Araport:AT5G45900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATAPG7; ATATG7; ATG7; AUTOPHAGY 7; AUTOPHAGY-RELATED 7; K15I22.10; K15I22_10; PEROXISOME UNUSUAL POSITIONING 4; PEUP4
Summary: Component of autophagy conjugation pathway. Required for proper senescence. Contributes to plant basal immunity towards fungal infection.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See APG7 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 11

Sequence:: Chromosome: 5; NC_003076.8 (18615175..18618597)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

After screening mutagenized lon2-2 seedlings for restored indole-3-butyric acid responsiveness, stabilization and processing of peroxisomal proteins, levels of several ATG proteins, and levels of the selective autophagy receptor NBR1/At4g24690, which accumulates when autophagy is impaired, were evaluated. The study recovered 21 alleles disrupting 6 ATG genes: ATG2, ATG3, ATG5, ATG7, ATG16, and ATG18a.
Title: A facile forward-genetic screen for Arabidopsis autophagy mutants reveals twenty-one loss-of-function mutations disrupting six ATG genes.
Overexpression of ATG5 or ATG7 stimulates Atg8 lipidation, autophagosome formation, and autophagic flux. It also induces transcriptional changes opposite to those observed in atg5 and atg7 mutants, favoring stress resistance and growth.
Title: Transcriptional stimulation of rate-limiting components of the autophagic pathway improves plant fitness.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_123958.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables Atg8 activating enzyme activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within defense response to fungus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within leaf senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf senescence	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of leaf senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein lipidation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: ThiF family protein

NP_568652.1

AUTOPHAGY 7 (APG7); FUNCTIONS IN: APG8 activating enzyme activity; INVOLVED IN: autophagy, protein amino acid lipidation, leaf senescence, aging; LOCATED IN: cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: E1-like protein-activating enzyme Gsa7p/Apg7p (InterPro:IPR006285), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

18615175..18618597

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123958.3 → NP_568652.1 ThiF family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568652.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94CD5, Q9FJ46

UniProtKB/TrEMBL

A0A178UF73

Conserved Domains (1) summary

TIGR01381
Location:13 → 681

E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p