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KCO2 Ca2+ activated outward rectifying K+ channel 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834680, updated on 18-Sep-2024

Summary

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Official Symbol
KCO2
Official Full Name
Ca2+ activated outward rectifying K+ channel 2
Primary source
TAIR:AT5G46370
Locus tag
AT5G46370
See related
Araport:AT5G46370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATKCO2; ATTPK2; Ca2+ activated outward rectifying K+ channel 2; CA2+ ACTIVATED OUTWARD RECTIFYING K+ CHANNEL 2; MPL12.17; MPL12_17; TANDEM PORE K+ CHANNEL 2
Summary
Encodes AtTPK2 (KCO2), a member of the Arabidopsis thaliana K+ channel family of AtTPK/KCO proteins. AtTPK2 is targeted to the vacuolar membrane. May form homomeric ion channels in vivo.
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Genomic context

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See KCO2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
2
Sequence:
Chromosome: 5; NC_003076.8 (18809496..18811870, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ca2+ activated outward rectifying K+ channel 3 Neighboring gene Serine/Threonine-kinase, putative (DUF1296) Neighboring gene Peptidase S41 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Photosynthesis in Arabidopsis Is Unaffected by the Function of the Vacuolar K(+) Channel TPK3. Höhner R, et al. Plant Physiol, 2019 Jul. PMID 31053658, Free PMC Article
  2. Members of the Arabidopsis AtTPK/KCO family form homomeric vacuolar channels in planta. Voelker C, et al. Plant J, 2006 Oct. PMID 16984403
  3. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables outward rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plant-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ca2+ activated outward rectifying K+ channel 2
NP_199449.1
  • Ca2+ activated outward rectifying K+ channel 2 (KCO2); FUNCTIONS IN: outward rectifier potassium channel activity, calcium ion binding; INVOLVED IN: potassium ion transport; LOCATED IN: plant-type vacuole membrane; EXPRESSED IN: sperm cell; CONTAINS InterPro DOMAIN/s: Potassium channel, two pore-domain (InterPro:IPR003280), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Ion transport 2 (InterPro:IPR013099); BEST Arabidopsis thaliana protein match is: Ca2+ activated outward rectifying K+ channel 6 (TAIR:AT4G18160.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    18809496..18811870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124007.3 → NP_199449.1  Ca2+ activated outward rectifying K+ channel 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199449.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1PDM4, Q9FL25, Q9SCY7
    UniProtKB/TrEMBL
    A0A178UQZ6, A0A5S9YC62, A0A7G2FIL3
    Conserved Domains (1) summary
    pfam07885
    Location:152 → 233
    Ion_trans_2; Ion channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FL25.1

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