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Disease resistance protein (TIR-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834695, updated on 18-Sep-2024

Summary

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Official Full Name
Disease resistance protein (TIR-NBS-LRR class) family
Primary source
TAIR:AT5G46520
Locus tag
AT5G46520
See related
Araport:AT5G46520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
K11I1.11; K11I1_11; VARIATION IN COMPOUND TRIGGERED ROOT growth response; VICTR
Summary
VICTR (VARIATION IN COMPOUND TRIGGERED ROOT growth response) encodes a TIR-NB-LRR (for Toll-Interleukin1 Receptor-nucleotide binding-Leucine-rich repeat) protein. VICTR is necessary for DFPM-induced root growth arrest and inhibition of abscisic acid-induced stomatal closing (DFPM is [5-(3,4-dichlorophenyl)furan-2-yl]-piperidine-1-ylmethanethione)(PMID:21620700). DFPM-mediated root growth arrest is accession-specific and depends on EDS1 and PAD4; Col-0 has a functional copy of VICTR. Induction of the VICTR gene by DFPM treatment requires functional VICTR (Col). A close homolog to VICTR, named VICTL (At5g46510) lies in tandem with VICTR.
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Genomic context

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Location:
chromosome: 5
Exon count:
6
Sequence:
Chromosome: 5; NC_003076.8 (18867616..18872494)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene protein VARIATION IN COMPOUND TRIGGERED ROOT growth protein Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family Neighboring gene ncRNA Neighboring gene AWPM-19-like family protein Neighboring gene P-glycoprotein 7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NLR locus-mediated trade-off between abiotic and biotic stress adaptation in Arabidopsis. Ariga H, et al. Nat Plants, 2017 May 26. PMID 28548656
  2. The Functional Association of ACQOS/VICTR with Salt Stress Resistance in Arabidopsis thaliana Was Confirmed by CRISPR-Mediated Mutagenesis. Kim ST, et al. Int J Mol Sci, 2021 Oct 21. PMID 34768819, Free PMC Article
  3. Natural variation in small molecule-induced TIR-NB-LRR signaling induces root growth arrest via EDS1- and PAD4-complexed R protein VICTR in Arabidopsis. Kim TH, et al. Plant Cell, 2012 Dec. PMID 23275581, Free PMC Article
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Functional Association of ACQOS/VICTR with Salt Stress Resistance in Arabidopsis thaliana Was Confirmed by CRISPR-Mediated Mutagenesis.
    Title: The Functional Association of ACQOS/VICTR with Salt Stress Resistance in Arabidopsis thaliana Was Confirmed by CRISPR-Mediated Mutagenesis.
  2. the locus responsible for acquired osmotolerance
    Title: NLR locus-mediated trade-off between abiotic and biotic stress adaptation in Arabidopsis.
  3. Data demonstrate that VICTR associates with EDS1 and PAD4 in a nuclear protein complex. Transgenic expression of the Col-0 VICTR allele in DFPM-insensitive Arabidopsis accessions recapitulated the DFPM-induced root growth arrest.
    Title: Natural variation in small molecule-induced TIR-NB-LRR signaling induces root growth arrest via EDS1- and PAD4-complexed R protein VICTR in Arabidopsis.
Submit: New GeneRIF Correction

General gene information

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NM_124022.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ADP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of root meristem growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Disease resistance protein (TIR-NBS-LRR class) family
NP_199464.2
  • Disease resistance protein (TIR-NBS-LRR class) family; FUNCTIONS IN: transmembrane receptor activity, nucleoside-triphosphatase activity, nucleotide binding, ATP binding; INVOLVED IN: signal transduction, defense response, apoptosis, innate immune response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT5G46510.1); Has 17530 Blast hits to 12991 proteins in 492 species: Archae - 6; Bacteria - 943; Metazoa - 980; Fungi - 57; Plants - 15109; Viruses - 15; Other Eukaryotes - 420 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    18867616..18872494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001344692.1 → NP_001330914.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BC84, A0A1Y1BZV2

  2. NM_124022.3 → NP_199464.2  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199464.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4KHI3, Q0WVG8, Q9FHF3
    UniProtKB/TrEMBL
    A0A1Y1BZS1, A0A1Y1BZV2
    Conserved Domains (3) summary
    sd00031
    Location:774 → 797
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:656 → 678
    LRR_RI; leucine-rich repeat [structural motif]
    cl27891
    Location:1 → 1163
    LRR_3; Leucine Rich Repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4KHI3.1

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