Ugdh UDP-glucose 6-dehydrogenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ugdhprovided by RGD
Official Full Name: UDP-glucose 6-dehydrogenaseprovided by RGD
Primary source: RGD:621879
See related: EnsemblRapid:ENSRNOG00000002643 AllianceGenome:RGD:621879
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables UDP-glucose 6-dehydrogenase activity. Predicted to be involved in several processes, including UDP-glucuronate biosynthetic process; protein hexamerization; and proteoglycan biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 84. Orthologous to human UGDH (UDP-glucose 6-dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 505.6), Kidney (RPKM 434.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (43202480..43226002)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (42848704..42872351)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (44479614..44502845)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D14Got48 (e-PCR)
- UniSTS:114714

BF403257 (e-PCR)
- UniSTS:246367

RH143560 (e-PCR)
- UniSTS:232806

RH134455 (e-PCR)
- UniSTS:217735

Ugdh (e-PCR), detects polymorphism
- UniSTS:507302

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables UDP-glucose 6-dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-glucose 6-dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables UDP-glucose 6-dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in UDP-glucuronate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UDP-glucuronate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in UDP-glucuronate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in chondroitin sulfate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in chondroitin sulfate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in chondroitin sulfate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in gastrulation with mouth forming second	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
involved_in gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
involved_in gastrulation with mouth forming second	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycosaminoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron development	ISO Inferred from Sequence Orthology more info
involved_in neuron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein hexamerization	ISO Inferred from Sequence Orthology more info
involved_in protein hexamerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: UDP-glucose 6-dehydrogenase

Names: UDP-Glc dehydrogenase; UDP-GlcDH; UDP-glucose dehydrogeanse; UDP-glucose dehydrogenase; UDPGDH

NP_112615.2

EC 1.1.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031325.2 → NP_112615.2 UDP-glucose 6-dehydrogenase

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

O70199

UniProtKB/TrEMBL

A6JDD9

Related

ENSRNOP00000003691.4, ENSRNOT00000003691.5

Conserved Domains (1) summary

PLN02353
Location:4 → 464

PLN02353; probable UDP-glucose 6-dehydrogenase