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FPS1 farnesyl diphosphate synthase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834828, updated on 18-Sep-2024

Summary

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Official Symbol
FPS1
Official Full Name
farnesyl diphosphate synthase 1
Primary source
TAIR:AT5G47770
Locus tag
AT5G47770
See related
Araport:AT5G47770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
farnesyl diphosphate synthase 1; FARNESYL DIPHOSPHATE SYNTHASE 1; MCA23.9; MCA23_9
Summary
Encodes a protein with farnesyl diphosphate synthase activity.
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Genomic context

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See FPS1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Sequence:
Chromosome: 5; NC_003076.8 (19345110..19347677)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Sec14p-like phosphatidylinositol transfer family protein Neighboring gene ncRNA Neighboring gene Adenine nucleotide alpha hydrolases-like superfamily protein Neighboring gene D6 protein kinase like 2 Neighboring gene 2-phosphoglycolate phosphatase 2 Neighboring gene galacturonosyltransferase 4 Neighboring gene miscRNA Neighboring gene SMAD/FHA domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of farnesyl diphosphate synthase in Arabidopsis mitochondria triggers light-dependent lesion formation and alters cytokinin homeostasis. Manzano D, et al. Plant Mol Biol, 2006 May. PMID 16786301
  2. Cloning of an Arabidopsis thaliana cDNA coding for farnesyl diphosphate synthase by functional complementation in yeast. Delourme D, et al. Plant Mol Biol, 1994 Dec. PMID 7858223
  3. Suppressing Farnesyl Diphosphate Synthase Alters Chloroplast Development and Triggers Sterol-Dependent Induction of Jasmonate- and Fe-Related Responses. Manzano D, et al. Plant Physiol, 2016 Sep. PMID 27382138, Free PMC Article
  4. Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds. Keim V, et al. PLoS One, 2012. PMID 23145086, Free PMC Article
  5. Formation of monoterpenes in Antirrhinum majus and Clarkia breweri flowers involves heterodimeric geranyl diphosphate synthases. Tholl D, et al. Plant Cell, 2004 Apr. PMID 15031409, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Farnesyl diphosphate synthase (FPS) single fps1 and fps2 knockout mutants are phenotypically indistinguishable from wild-type plants, while fps1/fps2 double mutants are embryo lethal.
    Title: Suppressing Farnesyl Diphosphate Synthase Alters Chloroplast Development and Triggers Sterol-Dependent Induction of Jasmonate- and Fe-Related Responses.
  2. Expression analysis of FPS genes in seeds showed that FPS1 and FPS2 display complementary patterns of expression particularly at late stages of seed development, which suggests that Arabidopsis seeds have two spatially segregated sources of FPP
    Title: Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds.
  3. Overexpression of FPS1L leads to mitochondrial dysfunction that renders plants more sensitive to the oxidative stress induced by continuous light. [FPS1L]
    Title: Overexpression of farnesyl diphosphate synthase in Arabidopsis mitochondria triggers light-dependent lesion formation and alters cytokinin homeostasis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_124151.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables dimethylallyltranstransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dimethylallyltranstransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables geranyltranstransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables geranyltranstransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within farnesyl diphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in farnesyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in geranyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in plastid HDA PubMed 

General protein information

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Preferred Names
farnesyl diphosphate synthase 1
NP_199588.1
  • farnesyl diphosphate synthase 1 (FPS1); FUNCTIONS IN: dimethylallyltranstransferase activity, geranyltranstransferase activity; INVOLVED IN: farnesyl diphosphate biosynthetic process, isoprenoid biosynthetic process; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Terpenoid synthase (InterPro:IPR008949), Polyprenyl synthetase (InterPro:IPR000092); BEST Arabidopsis thaliana protein match is: farnesyl diphosphate synthase 2 (TAIR:AT4G17190.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    19345110..19347677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124151.3 → NP_199588.1  farnesyl diphosphate synthase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199588.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09152, Q42573, Q8W504, Q93Y84
    UniProtKB/TrEMBL
    A0A178ULK1
    Conserved Domains (1) summary
    pfam00348
    Location:82 → 343
    polyprenyl_synt; Polyprenyl synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09152.2

Gene LinkOut

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